41926-06-1

Usage

Uses

Used in Pharmaceutical Industry:
1-METHYL-1H-INDAZOL-7-YLAMINE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic effects.
Used in Agrochemical Industry:
1-METHYL-1H-INDAZOL-7-YLAMINE is used as a precursor in the production of agrochemicals, facilitating the creation of compounds that can be utilized in agriculture for pest control and crop protection.
Used in Cancer Treatment Research:
1-METHYL-1H-INDAZOL-7-YLAMINE is studied for its potential use in the treatment of cancer, as it may contribute to the development of novel therapeutic agents that target and combat cancer cells.
Used in Antibacterial Treatment Research:
1-METHYL-1H-INDAZOL-7-YLAMINE is explored for its potential in treating bacterial infections, indicating its possible role in the creation of new antibiotics or compounds that can combat resistant bacteria.

InChI:InChI=1/C8H9N3/c1-11-8-6(5-10-11)3-2-4-7(8)9/h2-5H,9H2,1H3

Upstream product

• 58706-36-8 1‐methyl‐7‐nitro‐1H‐indazole 
• 77-78-1 dimethyl sulfate 
• 2942-42-9 7-Nitroindazole 

Downstream Products

• 369652-64-2 2-[(1-methyl-1H-indazol-7-yl)amino]-3-nitrobenzoic acid 
• 864724-72-1 4-methoxy-N-(1-methyl-1H-7-indazolyl)-benzenesulfonamide 

Relevant academic research and scientific papers

Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors

We herein describe a new synthesis of N-(7-indazolyl)benzenesulfonamide derivatives. These compounds were evaluated for their antiproliferative activities toward L1210 murine leukemia cells. One of them, 4-methoxy-N-(3- chloro-7-indazolyl)benzenesulfonamide, was identified as the most potent with an IC50 of 0.44 μM.

Reduction of nitroindazoles: Preparation of new amino and chloroamino derivatives

The synthesis of chloroaminoindazoles by the reduction of the nitro group of indazoles using stannous chloride in alcoholic acid solution is reported. Using catalytic hydrogenation with palladium the expected reduction to amino-indazoles occur.{A figure is presented}. Indazole Nitro Reduction Chlorination Aminochloroindazole Heterocycle.

New and efficient synthesis of bi- and trisubstituted indazoles

In this paper, the synthesis of bi- and trisubstituted indazoles was described. 4-Alkoxy-7-aminoprotected-indazole or 7-aminoprotected-indazole derivatives were prepared selectively using SnCl2 in alcohol or SnCl2 in ethyl acetate, r

Structure-activity relationships for pyrido-, imidazo-, pyrazolo-, pyrazino-, and pyrrolophenazinecarboxamides as topoisomerase-targeted anticancer agents

Heterocyclic phenazinecarboxamides were prepared by condensation of aminoheterocycles and 2-halo-3-nitrobenzoic acids, followed by reductive ring closure and amidation. They showed similar inhibition of paired cell lines that underexpressed topo II or overexpressed P-glycoprotein, indicating a non topo II mechanism of cytotoxicity and indifference to P-glycoprotein mediated multidrug resistance. Compounds with a fused five-membered heterocyclic ring were generally less potent than the pyrido[4,3-a]phenazines. A 4-methoxypyrido[4,3-a]phenazine (IC50s 2.5-26 nM) gave modest (ca. 5 day) growth delays in H69/P xenografts with oral dosing.