41927-89-3
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Basic information
- Product Name: FOLINIC ACID CALCIUM SALT PENTAHYDRATE
- Synonyms: N5-FORMYL-5,6,7,8-TETRAHYDROPTEROYL-L-GLUTAMIC ACID CALCIUM SALT PENTAHYDRATE;5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID CALCIUM SALT;5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID CALCIUM SALT PENTAHYDRATE;5-FORMYL-5,6,7,8-TETRAHYDROPTEROYL-L-GLUTAMIC ACID CALCIUM SALT PENTAHYDRATE;5-HCO-H4PTEGLU CALCIUM SALT PENTAHYDRATE;CALCIUM FOLINATE PENTAHYDRATE;LEUCOVORIN CALCIUM SALT PENTAHYDRATE;LEUCOVORIN PENTAHYDRATE
- CAS NO:41927-89-3
- Molecular Formula: C20H31CaN7O12
- Molecular Weight: 601.58
- EINECS: N/A
- Product Categories: N/A
- Mol File: 41927-89-3.mol
- Article Data: 0
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Chemical Properties
- Melting Point: 240-250 °C
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: 0-6°C
- Solubility: Aqueous (Slightly, Sonicated), Water (Sparingly, Heated, Sonicated)
- Stability: Hygroscopic
- CAS DataBase Reference: FOLINIC ACID CALCIUM SALT PENTAHYDRATE(CAS DataBase Reference)
- NIST Chemistry Reference: FOLINIC ACID CALCIUM SALT PENTAHYDRATE(41927-89-3)
- EPA Substance Registry System: FOLINIC ACID CALCIUM SALT PENTAHYDRATE(41927-89-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: 24/25
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 41927-89-3(Hazardous Substances Data)
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41927-89-3 Usage
Uses
Anti-anemic (folate deficiency); antidote (to folic acid antagonists).Brand name
Wellcovorin (GlaxoSmithKline).Clinical Use
Folinic acid rescue Enhancement of 5-fluorouracil cytotoxicity in advanced colorectal cancer Folate deficiencyDrug interactions
Potentially hazardous interactions with other drugs Should not be administered simultaneously with a folic acid antagonist as this may nullify the effect of the antagonist. Cytotoxics: avoid with panitumumab and raltitrexed.Metabolism
Folinic acid is a racemate where the L-form (L-5- formyl-tetrahydrofolate, L-5-formyl-THF), is the active enantiomer. The major metabolic product of folinic acid is 5-methyl-tetrahydrofolic acid (5-methyl-THF) which is predominantly produced in the liver and intestinal mucosa. 80-90% with the urine (5- and 10-formyltetrahydrofolates inactive metabolites), 5-8% with the faeces.Check Digit Verification of cas no
The CAS Registry Mumber 41927-89-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,9,2 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.Calculate Digit Verification of CAS Registry Number 41927-89:
(7*4)+(6*1)+(5*9)+(4*2)+(3*7)+(2*8)+(1*9)=133
133 % 10 = 3
So 41927-89-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H23N7O7.Ca.5H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;;;;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;5*1H2/t12?,13-;;;;;;/m0....../s1
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FOLINIC ACID CALCIUM SALT PENTAHYDRATE
