419541-48-3

Upstream product

• 60656-87-3 benzyloxyacetoaldehyde 
• 419541-63-2 1-(2-{(6R,2S)-4-methylene-6-[(phenylmethoxy)methyl](3,5,6-trihydro-2H-pyran-2-yl)}ethoxy)-2,2-dimethyl-1,1-diphenyl-1-silapropane 
• 419541-69-8 2-{(6R,2S)-4-methylene-6-[(phenylmethoxy)methyl]-3,5,6-trihydro-2H-pyran-2-yl}ethan-1-ol 

Downstream Products

• 940877-34-9 [(2S,6R)-6-benzyloxymethyl-4-methylene-tetrahydropyran-2-yl]-acetic acid 
• 940877-36-1 [(2S,6R)-6-benzyloxymethyl-4-methylene-tetrahydropyran-2-yl]-acetic acid (S)-1-[2-(tert-butyldiphenylsilanyloxy)ethyl]-3-chloromethyl-but-3-enyl ester 
• 940877-37-2 [(2S,6R)-6-benzyloxymethyl-4-methylene-tetrahydropyran-2-yl]-acetic acid (S)-1-[2-(tert-butyldiphenylsilanyloxy)ethyl]-3-iodomethyl-but-3-enyl ester 

Relevant academic research and scientific papers

A new construction of 2-alkoxypyrans by an acylation-reductive cyclization sequence

A new convergent synthetic approach to a pyran motif common to many naturally occurring structures is described. In this approach, two fragments are joined by esterification, and a subsequent intramolecular reductive cyclization affords the 2-hydroxypyran.

Pyran annulation: asymmetric synthesis of 2,6-disubstituted-4-methylene tetrahydropyrans.

[reaction: see text] A reaction process for the asymmetric construction of a variety of cis or trans disubstituted pyrans is described. This sequences allows for the asymmetric convergent union of two aldehydes with silyl-stannane reagent 1 in a two-step