419564-05-9Relevant academic research and scientific papers
Mechanism of the Glutathione Transferase-Catalyzed Conversion of Antitumor 2-Crotonyloxymethyl-2-cycloalkenones to GSH Adducts
Hamilton, Diana S.,Zhang, Xiyun,Ding, Zhebo,Hubatsch, Ina,Mannervik, Bengt,Houk,Ganem, Bruce,Creighton, Donald J.
, p. 15049 - 15058 (2007/10/03)
Human glutathione (GSH) transferase (hGSTP1-1) processes with similar kinetic efficiencies the antitumor agents 2-crotonyloxymethyl-2-cyclohexenone (COMC-6), 2-crotonyloxymethyl-2-cycloheptenone (COMC-7), and 2-crotonyloxymethyl-2-cyclopentenone (COMC-5)
Glutathionyl Transferase Catalyzed Addition of Glutathione to COMC: A New Hypothesis for Antitumor Activity
Hamilton, Diana S.,Ding, Zhebo,Ganem, Bruce,Creighton, Donald J.
, p. 1209 - 1212 (2007/10/03)
matrix presented Data are presented indicating that the potent antitumor activity of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxy-2-cyclohexenone (COTC) and 2-crotonyloxymethyl-2-cyclohexenone (COMC) is not likely the result of glyoxalase I inhibition,
