41973-43-7

Upstream product

• 41973-42-6 1,5-bis(2-methoxyphenyl) penta-1,4-dien-3-one 
• 100-46-9 benzylamine 
• 135-02-4 ortho-anisaldehyde 
• 39777-61-2 (1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one 

Downstream Products

• 137794-32-2 2,6-bis(2'-methoxybenzyl)-4-nitrophenol 
• 137794-35-5 2,6-bis(2'-methoxybenzyl)-4-nitrophenylacetate 

Relevant academic research and scientific papers

Tandem hydrogenation and condensation of fluorinated α,β-unsaturated ketones with primary amines, catalyzed by nickel

A simple homogeneous catalytic system based on nickel phosphine complexes has been developed for the transfer hydrogenation and condensation of α,β-unsaturated ketones to yield saturated ones and saturated imines using primary amines as hydrogen donors. Thus, a wide range of fluorinated 1,5-diaryl-1,4-pentadiene-3-ones were allowed to react with substituted benzylamines in the presence of [(dippe)Ni(μ-H)]2 (dippe = 1,2-bis-(diisopropylphosphino)-ethane) using ethanol as a solvent at 180 °C to give the corresponding saturated carbonyl compounds; here hydrogenation of the CC bond was preferred over the CO bond. Under the same reaction conditions but using an excess of benzylamine, a tandem process is then favoured, starting also with the reduction of the CC bond followed by a nucleophilic addition of the primary amine to yield valuable saturated imines with good to excellent yields (62%-91%).

Method and compounds for cancer treatment utilizing NFkB as a direct or ultimate target for small molecule inhibitors

A method is described for cancer treatment through NFκB inhibition. NFκB is a direct or ultimate target for small molecule inhibitors. These small molecule inhibitors are aimed at suppression of NFκB directly or by indirect suppression of IKK, SFK kinases, or other upstream kinases. The present invention includes small molecule inhibitors comprising three, five, and seven carbon unsaturated spacers having one or two carbonyls, flanked by substituted aryl rings. The small molecule inhibitors can be symmetrical or unsymmetrical.

New Crown Ether-like Macrocycles Containing a Nitrophenol Unit. Synthesis and Metal Ion Effects on the Reactivity of Their Acetates in Transacylation Reactions

A series of crown ether-like macrocyclic compounds 3 containing the 2,6-dibenzyl-4-nitrophenol structure have been prepared by cyclization reactions of disalicylideneacetone 4 with ditosylates 7 of oligoethylene glycols, followed by hydrogenation and double aldol condensation with nitromalondialdehyde.These compounds may be regarded as possessing a section of a 1,3-crowned calixarene.X-ray analysis of two examples shows, however, that the three phenolic units linked via o-methylene groups adopt a conformation different to the all-cis conformation found in calixarenes.The reaction of the nitrophenyl acetates derived from 3 and from suitable model compounds with ethoxide in ethanol was studied kinetically.This reaction is accelerated by the addition of SrBr2 and BaBr2 in all cases, indicating that the metal ion is bound more strongly to the transition state than to the initial state.Especially high acceleration factors (up to 700 in the case of 10e) were observed for cyclic and open-chain compounds with longer flexible oligoethylene oxide chains, which means that only in these cases do the ether oxygens contribute effectively to the binding of the metal ion in the transition state.

THE 2,2'-SPIROBICHROMAN - 1,1'-SPIROBIINDAN-4,4'-DIOL REARRANGEMENT. II

The reaction of 2,2'-spirobichroman derivatives with either hydrobromic acid in the acetic acid solution or aluminum chloride in the chlorobenzene solution yielded 1,1'-spirobiindan-4,4'-diol analogues.The reaction is peculiar as compared with the reaction of alkyl aryl ethers with the same reagents in the same media.