4201-22-3

Usage

Therapeutic Function

Antihypertensive

InChI:InChI=1/C10H12ClN3/c1-7-2-3-9(8(11)6-7)14-10-12-4-5-13-10/h2-3,6H,4-5H2,1H3,(H2,12,13,14)

Upstream product

• 61939-92-2 (2-chloro-4-methyl-phenyl)-(4,5-dihydro-1H-imidazol-2-yl)-prop-2-ynyl-amine 
• 41062-11-7 2-chloro-4-methylphenylcarbonimidoyl dichloride 

Downstream Products

• 72409-87-1 (2,5-dichloro-4-methyl-phenyl)-(4,5-dihydro-1H-imidazol-2-yl)-amine 

Relevant academic research and scientific papers

TREATMENT OF URINARY INCONTINENCE BY ADMINISTRATION OF ALPHA 1L-ADRENOCEPTOR AGONISTS

The present invention relates to the use of α lL-agonists for treating urinary incontinence.

Method of lowering intraocular pressure using phenylimino-imidazoles

A method is provided of treating glaucoma in a patient which comprises administering, preferably as eye drops, an effective amount of the compound STR1 which is preferably in the form of its hydrochloride. The compound is administered preferably in the form of a sterile pharmacologically acceptable solution which contains from 0.1 to 5, and more preferably 0.1 to 2.0, percent by weight of said compound. The patient preferably obtains the anti-glaucoma agent in the form of a kit which comprises the sterile pharmacologically acceptable solution and an eyedropper for dispensing said sterile pharmacologically acceptable solution to the affected eyes of a patient suffering from glaucoma.

Method for lowering intraocular pressure using phenylimino-imidazoles

2-(Trisubstituted phenylimino)-imidazole compounds also known as 2-(trisubstituted anilino)-1,3 diazacyclopentene-(2) compounds are used to lower intraocular pressure.

Compounds, compositions and methods for controlling pests

A new method of controlling pests harmful to domestic animals and certain novel pesticidal compositions are described. Compounds for use in the method have the formula STR1 in which n is 0 to 5, R is halo, alkyl, trihaloalkyl, cyano alkoxy or alkoxycarbon

Propargyl-substituted 2-phenylamino-2-imidazolines and salts thereof

Compounds of the formula STR1 wherein R1, R2 and R3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, methyl, ethyl, methoxy or trifluoromethyl, and R4 and R5 are each hydrogen or propargyl, but other than both hydrogen or both propargyl at the same time, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as analgesics and hypotensives.

Cardiovascular activity of aromatic guanidine compounds.

A series of aromatic guanidines and several 1-phenylbiguanides was prepared and tested for cardiovascular (CV) effects in anesthetized dogs measuring heart rate, blood pressure, carotid artery blood flow, and myocardial force changes. The predominant CV effect at minimally effective dose was vasoconstriction unassociated with cardiac stimulation. The structure-activity relationships of the compounds were discussed comparing their structural similarities to the beta-phenylethylamines. The most potent members of the series were phenylguanidines substituted in the 3 and 4 positions on the aromatic nucleus with hydroxy or chloro groups. Preliminary mechanism studies indicated that the 3,4-dihydroxyphenylguanidines act at least partially by a direct alpha-adrenergic mechanism