420106-35-0Relevant academic research and scientific papers
Solvent free microwave accelerated synthesis of heterocyclic thiazolidin-4-ones as antimicrobial and antifungal agents
Sekhar, Kondapalli Venkata Gowri Chandra,Rao, Vajja Sambasiva,Reddy, Aravalli Satish,Sunandini, Ravada,Kumar Satuluri
scheme or table, p. 1219 - 1222 (2010/09/18)
A simple and efficient method has been developed for conversion of arenecarbaldehyde-3-methylquinoxalin-2-ylhydrazones to 3-(2-methylquinoxalin-3- yl)-2-(substitutedphenyl)thiazolidin-4-ones in good yields using microwave irradiation technique on silica a
Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead
Williams, Richard,Niswender, Colleen M.,Luo, Qingwei,Le, Uyen,Conn, P. Jeffrey,Lindsley, Craig W.
experimental part, p. 962 - 966 (2009/09/25)
This Letter describes the synthesis and SAR of two mGluR4 positive allosteric modulator leads, 6 and 7. VU001171 (6) represents the most potent (EC50 = 650 nM), efficacious (141% Glu Max) and largest fold shift (36-fold) of any mGluR4 PAM repor
Synthesis and antimicrobial activity of 2-substituted benzyl hydrazino-3-methyl quinoxalines
Vyas,Chauhan,Parikh
, p. 972 - 974 (2007/10/03)
Reduction of 3-methyl-2-(arylidcne hydrazino)quinoxalines 5a-1 with NaBH4 in controlled experimental conditions to give the 2-substituted benzyl hydrazine-3-methyl quinoxalines 6a-l have been described. The structure of compounds 6a-l have been confirmed from elemental analysis, IR, 1H NMR and mass spectral data. All the compounds have been screened for their antimicrobial activity against several microbes.
