420106-65-6Relevant academic research and scientific papers
NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION
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Page/Page column 203-204, (2011/07/06)
The embodiments provide compounds of the general Formulae I, II, III, IV, or V as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
Small molecule antagonists of the CC chemokine receptor 4 (CCR4)
Burdi, Douglas F.,Chi, Shannon,Mattia, Karen,Harrington, Celeste,Shi, Zhan,Chen, Shaowu,Jacutin-Porte, Swanee,Bennett, Robert,Carson, Kenneth,Yin, Wei,Kansra, Vikram,Gonzalo, Jose-Angel,Coyle, Anthony,Jaffee, Bruce,Ocain, Timothy,Hodge, Marty,LaRosa, Gregory,Harriman, Geraldine
, p. 3141 - 3145 (2008/09/21)
The identification, optimization, and structure-activity relationship (SAR) of small-molecule CCR4 antagonists is described. An initial screening hit with micromolar potency was identified that was optimized to sub-micromolar binding potency by enantiomer
