420137-06-0Relevant academic research and scientific papers
Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides
Borza, István,Bozó, éva,Barta-Szalai, Gizella,Kiss, Csilla,Tárkányi, Gábor,Demeter, ádám,Gáti, Tamás,Háda, Viktor,Kolok, Sándor,Gere, Anikó,Fodor, László,Nagy, József,Galgóczy, Kornél,Magdó, Ildikó,ágai, Béla,Fetter, József,Bertha, Ferenc,Keserü, Gy?rgy M.,Horváth, Csilla,Farkas, Sándor,Greiner, István,Domány, Gy?rgy
, p. 901 - 914 (2007)
(4-Benzylpiperidine-1-yl)-(6-hydroxy-1H-indole-2-yl)-methanone (6a) derived from (E)-1 -(4-benzylpiperidin-1-yl)-3-(4-hydroxy-phenyl)-propenone (5) was identified as a potent NR2B subunit-selective antagonist of the NMDA receptor. To establish the structu
Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists
Borza, Istvan,Kolok, Sandor,Gere, Aniko,Agai-Csongor, Eva,Agai, Bela,Tarkanyi, Gabor,Horvath, Csilla,Barta-Szalai, Gizella,Bozo, Eva,Kiss, Csilla,Bielik, Attila,Nagy, Jozsef,Farkas, Sandor,Domany, Gyoergy
, p. 3859 - 3861 (2007/10/03)
A novel series of indole-2-carboxamide derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the number and position of OH groups on the indole skeleton as well as the substitution of the piperidine ring on
