42019-12-5Relevant academic research and scientific papers
Effect of stilbene and chalcone scaffolds incorporation in clofibric acid on PPARα agonistic activity
Giampietro, Letizia,D'Angelo, Alessandra,Giancristofaro, Antonella,Ammazzalorso, Alessandra,De Filippis, Barbara,Di Matteo, Mauro,Fantacuzzi, Marialuigia,Linciano, Pasquale,Maccallini, Cristina,Amoroso, Rosa
, p. 59 - 65 (2014)
In an effort to develop safe and efficacious compounds for the treatment of metabolic disorders, new compounds based on a combination of clofibric acid, the active metabolite of clofibrate, and trans-stilbene, chalcone, and other lipophilic groups were synthesized. They were evaluated for PPARα transactivation activity; all branched derivatives showed an increase of the transcriptional activity of receptor compared to the linear ones. Noteworthy, stilbene and benzophenone branched derivatives activated the PPARα better than clofibric acid.
Halocyclopropyl substituted phenoxyalkanoic acids
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, (2008/06/13)
Halocyclopropyl substituted phenoxyalkanoic acids and esters thereof, having hypocholesteremic activity are prepared via several alternative synthetic approaches, involving as the key reactions interaction of a substituted phenylalkene with a carbene source to introduce the halocyclopropyl moiety, and reaction of a substituted phenol with chloroform and a lower-alkanone in the presence of base, or with a lower-alkyl α-bromo-alkanoate, to form the phenoxyalkanoic acid moiety.
