42022-52-6

Upstream product

• 4755-77-5 Ethyl oxalyl chloride 
• 643-28-7 2-isopropylaniline 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 1266620-44-3 C₂₀H₃₁N₃O₂ 
• 42022-37-7 N-Hydroxy-N'-(2-isopropylphenyl)-oxamid 

Relevant academic research and scientific papers

Visible light-mediated photocatalytic oxidative cleavage of activated alkynes: Via hydroamination: A direct approach to oxamates

The direct oxidative cleavage of activated alkynes via hydroamination has been described using organic photocatalyst under visible-light irradiation at room temperature. In this reaction, the single electron oxidation of an in situ formed enamine followed by radical coupling with an oxidant finally delivers the oxamate. The key features of this photocatalytic reaction are the mild reaction conditions, metal-free organic dye as a photocatalyst, and TBHP playing a dual role as O source and for the regeneration of the photocatalyst.

C1-Symmetric Atropisomeric NHC Palladium(II) Complexes: Synthesis, Resolution and Characterization

Series of chiral palladium(II) allyl and cinnamyl complexes bearing a C1-symmetric N-heterocyclic carbenes were synthesized from achiral precursors. The chirality of theses complexes results from the formation of the carbene-palladium bond whic

MANUFACTURING INTERMEDIATE AND MANUFACTURING METHOD OF POLYMERIZABLE COMPOUND

PROBLEM TO BE SOLVED: To provide a manufacturing intermediate hardly generating discoloration and change of haze, when ultraviolet is radiated to a film-shaped polymer obtained by manufacturing a polymerizable compound and polymerizing a polymerizable composition containing the compound, and a manufacturing method of the manufacturing intermediate. SOLUTION: There are provided a compound represented by the formula (II), a manufacturing method of the compound, a polymerizable compound manufactured from the compound, a polymerizable composition, a polymer obtained by polymerizing the polymerizable composition, and an optical isomer using the polymer. In the formula, R1, R2 and L1 represent organic groups, n1 represents an integer of 1 to 4, when a plurality of L1 exist, it may be same or different, and neighboring L1 each other may form a condensed ring. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

PRODUCTION METHOD OF BENZOTHIAZOLE DERIVATIVE

PROBLEM TO BE SOLVED: To provide: a production method of a benzothiazole derivative; as well as a production method of a polymerizable compound produced from the benzothiazole derivative; a polymerizable composition including the polymerizable compound; a polymer obtained by polymerizing the polymerizable composition; and an optical isomer utilizing the polymer. SOLUTION: A production method of a compound represented by the following general formula (III) is provided, and also a production method of a polymerizable compound produced from the compound represented by the general formula (III), a polymerizable composition, a polymer obtained by polymerizing the polymerizable composition, and an optical isomer utilizing the polymer are provided. When the polymerizable composition containing the compound is polymerized and the obtained film-like polymer is irradiated with ultraviolet light, change of color and change of phase difference scarcely take place. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening

The low-molecular-weight compound JRC-II-191 inhibits infection of HIV-1 by blocking the binding of the HIV-1 envelope glycoprotein gp120 to the CD4 receptor and is therefore an important lead in the development of a potent viral entry inhibitor. Reported here is the use of two orthogonal screening methods, gold docking and ROCS shape-based similarity searching, to identify amine-building blocks that, when conjugated to the core scaffold, yield novel analogs that maintain similar affinity for gp120. Use of this computational approach to expand SAR produced analogs of equal inhibitory activity but with diverse capacity to enhance viral infection. The novel analogs provide additional lead scaffolds for the development of HIV-1 entry inhibitors that employ protein-ligand interactions in the vestibule of gp120 Phe 43 cavity.

SUBSTITUTED TRIAZOLECARBOXAMIDES

Substituted triazolecarboxamides A b s t r a c t The invention relates to substituted triazolecarboxamides of the formula (I) in which R1, R2, R3 and R4 are as defined in the description, to their use as crop treatment agents, in particular as herbicides,