4205-06-5

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-NITRO-PHENYL)-1H-IMIDAZOLE is used as a potential drug candidate for its antifungal properties, targeting fungal infections by inhibiting essential enzymes or pathways in fungi, thereby disrupting their growth and survival.
2-(2-NITRO-PHENYL)-1H-IMIDAZOLE is also used as a potential drug candidate for its antiparasitic properties, showing activity against various parasites that cause diseases in humans and animals, offering a new avenue for treatment and control of parasitic infections.
Used in Enzyme Inhibition Research:
2-(2-NITRO-PHENYL)-1H-IMIDAZOLE is used as an enzyme inhibitor in research settings to study its effects on specific enzymes that play a role in disease processes, potentially leading to the development of targeted therapies for various conditions.
Used in Oncology Research:
2-(2-NITRO-PHENYL)-1H-IMIDAZOLE is used as an anti-cancer agent in research, exploring its potential to inhibit cancer cell growth, induce cell death, or disrupt cancer-related pathways, offering a new therapeutic approach for cancer treatment.
While the provided materials do not specify different industries for the uses of 2-(2-NITRO-PHENYL)-1H-IMIDAZOLE, the applications listed above are based on the general potential pharmacological activities mentioned. Further studies and development may reveal additional applications across various industries.

Upstream product

• 98-95-3 nitrobenzene 
• 50846-98-5 2-Diazo-2H-imidazole 
• 131543-46-9 Glyoxal 
• 552-89-6 2-nitro-benzaldehyde 
• 7664-93-9 sulfuric acid 
• 288-32-4 1H-imidazole 
• 88-74-4 2-nitro-aniline 
• 4405-13-4 glyoxal trimer dihydrate 

Downstream Products

• 29528-25-4 2-(2-aminophenyl)-1H-imidazole 
• 1160826-43-6 C₁₆H₁₀N₄O₅ 
• 1160826-50-5 C₁₆H₁₀BrN₃O₃ 
• 1327242-43-2 1-(4-nitrophenyl)-3-[2-(1H-imidazol-2-yl)phenyl]urea 
• 1327242-44-3 1-(4-nitrophenyl)-3-[2-(1H-imidazol-2-yl)phenyl]thiourea 
• 1327242-45-4 1-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(1H-imidazol-2-yl)phenyl]urea 
• 1400866-34-3 C₁₇H₁₄N₄O₃ 
• 1400866-36-5 C₁₉H₁₈N₄O₃ 
• 1400866-37-6 C₁₈H₁₆N₄O₃ 
• 1400866-38-7 N-(2,4-dinitrophenyl)-2-(2-(2-nitrophenyl)-1H-imidazol-2-yl)propanamide 
• 1335144-93-8 C₁₅H₁₀N₄O₃ 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR TREATING CANCER

Substituted cinnamamide compounds and analogs, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or ameliorate cancer are provided.

Synthesis, antimicrobial activities and binding mode analysis of some novel N-substituted imidazoles and nitroimidazoles

Novel N-((2-(aryl)-imidazol-1-yl) methyl)-anilines 2a-n and 1-(3'-arylamino-2'- hydroxypropyl)-2-methyl-4-nitroimidazoles 4a-g have been synthesized. The compounds have been characterized on the basis of elemental analysis and spectral data. All the compounds were evaluated for their antibacterial activities. Among the synthesized compounds, compounds 2m, 2n and compounds 4c, 4e exhibited highest inhibitory activity against all the bacterial strains, comparable to the standard drug ciprofloxacin. Binding mode analysis of the highest active compounds was carried out in the active site of GlcN-6-P synthase (2VF5).

Reactivity of hydroxy and amino derivatives of 2-phenyl-1H-imidazoline and 2-phenyl-1H-imidazole toward isocyanates: Synthesis of appropriate carbamates and ureas

Reactivity of 2-(4-hydroxyphenyl)-1H-imidazoline and 2-(4-hydroxyphenyl)- 1H-imidazole toward substituted phenyl isocyanates was studied. When mentioned imidazoline was treated with 2.5 equiv of substituted phenyl isocyanate, three N,O-dicarboxamides were

Synthesis, antimycobacterial activities and Docking studies of some novel diaryl imidazoles targeted at mycobacterium tuberculosis P-45014DM

A novel series of nine 2-(substituted phenyl)-1H-imidazol-1-yl-N- (substituted phenyl) alkanamides 3a-i were synthesized by reacting the corresponding w-chloroalkanamides 1 with 2-(substituted phenyl)-1H-imidazoles 2 in dimethylformamide. The compounds have been characterized on the basis of elemental analysis and spectral data. All the compounds were evaluated for their antimycobacterial activity. Among the synthesized compounds, N-(2,4-dinitrophenyl)-2-(2-(2-nitrophenyl)-1 H-imidazol-2-yl) propanamide 3e showed significant antimycobacterial activity when compared with the standard drug ethambutol. Docking studies with 14-a-demethylase (PDB ID IEA1) were also performed in order to investigate the binding pattern of these compounds.

Synthesis, antimicrobial and antimycobacterial evaluation of [2-(substituted phenyl)-imidazol-1-yl]-pyridin-3-yl-methanones

A series of [2-(substituted phenyl)-imidazol-1-yl]-pyridin-3-yl-methanones (111) were synthesized and screened for their antimicrobial and antimycobacterial activities. Further, a series of [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones (1220) reported in our earlier study was also screened for their antimycobacterial activity. The antimycobacterial activity results indicated that [2-(4-Nitro-phenyl)-imidazol- 1-yl]-pyridin-3-yl-methanone (8, minimum inhibitory concentration [MIC]=3.13 g) was equipotent as standard drug ciprofloxacin and [2-(4-Nitro-phenyl)- benzimidazol-1-yl]-pyridin-3-yl-methanone (16, MIC=1.56 g) was equipotent as standard drug ethambutol. The results of antimicrobial screening demonstrated that 2-[1-(Pyridine-3-carbonyl)-1H-imidazol-2-yl]-benzoic acid (compound 11, MIC=0.002 g) was two times more effective than standard drug ciprofloxacin (MIC=0.004 g) against tested bacterial strains and [2-(2,5-Dimethyl-phenyl)- imidazol-1-yl]-pyridin-3-yl-methanone (compound 3, MIC=0.005 g) was equipotent to the reference compound, fluconazole against tested fungal strains.

Clay-supported 2-phenyl-1H-imidazole derivatives for heterogeneous catalysis of Henry reaction

Figure represented. Six derivatives (1-6) of 2-phenyl-1H-imidazole were tested as catalysts of Henry reaction. Three new (4-6) 2-phenyl-1H-imidazole derivatives, differently substituted (thio)ureas, were synthesized and determined by 1H NMR and

Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives

In the present study, we have synthesized 2-(substituted phenyl)-1H-imidazole (1-12) and (substituted phenyl)-[2-(substituted phenyl)-imidazol-1-yl]-methanone (13-26) analogues and screened them for their antimicrobial activity against Gram positive, Gram negative and fungal species. The results of antibacterial study indicated that compounds 15, 17 and 24 showed appreciable antibacterial activity and compound 26 emerged as the most potential antifungal agent. The results of SAR studies indicated that the presence of electron withdrawing groups is necessary for the antimicrobial activity of the synthesized compounds. The results of the present study indicated that compounds 15, 17 and 24 might be of interest for the identification of new antimicrobial molecules as their antibacterial activity is equivalent to the standard drug norfloxacin. Further, the antiviral screening of (substituted phenyl)-[2-(substituted phenyl)-imidazol-1-yl]-methanones (13-26) against a panel of viral strains indicated that compounds 16 and 19 can be selected as lead compounds for the development of novel antiviral agents.

Imidazo[1,2-c]quinazolines with lipid peroxidation inhibitory effect

A series of imidazo[1,2-c]quinazolines of different lipophilic character was prepared. According to their antioxidant (cyclic voltammetry) properties they all should be potent inhibitors of lipid peroxidation. Under the given circumstances (NADPH-induced lipid peroxidation in rat brain microsomes and Fe2+-induced lipid peroxidation in rat brain homogenate), however, their lipid peroxidation inhibitory activity was strongly dependent on their lipophilicity.

2,5-DIAZACYCLOPENTADIENYLIDENE: A STANDARD CARBENE OR A HIGHLY REACTIVE DIRADICAL?

2,5-Diazacyclopentadienylidene (2H-imidazolidene), generated either by photolysis or thermolysis from 2-diazo-2H-imidazole, reacts with benzene derivatives to give mainly a mixture of o-, m-, p-substitued 2-phenylimidazoles.The carbene shows a strong diradical character, in sharp contrast with the well-known behavior of cyclopentadienylidene.