42055-16-3

Usage

Uses

Used in Pharmaceutical Industry:
3-(Ethylamino)propan-1-ol is used as an organic reagent for the synthesis of Amodiaquine analogs, which are crucial in the treatment of cerebral malaria. Amodiaquine is an antimalarial drug that has been widely used for its effectiveness against Plasmodium falciparum, the parasite responsible for causing severe and life-threatening forms of malaria. EAOP plays a vital role in the production of these life-saving drugs by facilitating the synthesis of the active pharmaceutical ingredients.

Upstream product

• 199595-92-1 1-Ethyl-1,4,5,6-tetrahydro-[1,2,3]triazine 

Downstream Products

• 95290-49-6 Benzilsaeure- 
• 138609-43-5 3-ethyl-2-(4-chlorophenyl)tetrahydro-1,3-oxazine 
• 39885-23-9 3-ethyl-2-(4-nitro-phenyl)-[1,3]oxazinane 
• 138609-42-4 3-ethyl-2-phenyltetrahydro-1,3-oxazine 
• 138609-49-1 2-ethyl-7-phenyltetrahydro-1,6,2-dioxazepine 
• 138609-50-4 2-ethyl-7-(4-chlorophenyl)tetrahydro-1,6,2-dioxazepine 
• 138609-51-5 2-ethyl-7-(4-nitrophenyl)tetrahydro-1,6,2-dioxazepine 
• 182951-96-8 tert-butyl ethyl-(3-hydroxypropyl)carbamate 
• 1300743-16-1 7-chloro-4-{[3-({ethyl[3-(nitrooxy)propyl]ammonio}methyl)-4-hydroxyphenyl]amino}quinoline 
• 1218904-24-5 2-{5-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-3-yl}-N-(3-fluorophenyl)acetamide 

Relevant academic research and scientific papers

Triazinines: Synthesis and proteolytic decomposition of a new class of cyclic triazenes

The reaction of 1-azido-3-chloropropane with various Grignard reagents and subsequent treatment with anhydrous isopropylamine results in the formation of the corresponding azimine. If the initial magnesium-triazene complex if first hydrolyzed with Dowex resin and then concentrated, the resultant linear triazene begins self-catalyzed cyclization to form the six- membered-ring triazenes as the major product, with HCl as the byproduct. Addition of an amine, at reduced temperature, allows for the neutralization of the byproduct, HC1, which would otherwise react with the linear triazene and the cyclic six-membered-ring triazene to form hydrolysis products. We have assigned the trivial name of triazinines to this new class of cyclic triazenes. The hydrolytic decomposition of these compounds in mixed acetonitrile-aqueous buffers predominantly forms 3-(alkylamino)-1-propanol and lesser amounts of the rearranged alcohol 1-(alkylamino)-2-propanol and N- alkyl-2-propenamine. The rate of hydrolysis of 1-alkyltriazinines is approximately equal to that of the analogous 1,3,3-trialkyltriazenes, about three times slower than that of the analogous 1-alkyltriazolines, and varies in the order ethyl > butyl > 3,3-diethoxypropyl > benzyl. As was true for other triazenes, the mechanism of the decomposition was found to be specific acid-catalyzed (A1), involving rapid reversible protonation followed by rate- limiting formation of a 3-(alkylamino)propyldiazonium ion. The slopes of the log k(obs) versus pH plots were near -1.0 The solvent deuterium isotope effect, k(H)2O/k(D)2O, was in all cases 1.0 and ranges from 0.82 for 1- benzyltriazinine to 0.89 for 1-ethyltriazinine. The activation parameters of the proteolytic decomposition of a series, 1-ethyltriazinine, 1- ethyltriazoline, 1,3,3-triethyltriazene, and 1-ethyl-3-methyltriazene, had similar values for ΔH(+) (+9 → 12 kcal/mol) and ΔS(+) (+7 → 15 eu), respectively.