42057-01-2

Basic information

• Product Name: 3-(p-tolyloxy)thiophene
• Synonyms: 3-(p-tolyloxy)thiophene
• CAS NO: 42057-01-2
• Molecular Weight: 190.266
• Mol File: 42057-01-2.mol

Chemical Properties

• CAS DataBase Reference: 3-(p-tolyloxy)thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(p-tolyloxy)thiophene(42057-01-2)
• EPA Substance Registry System: 3-(p-tolyloxy)thiophene(42057-01-2)

Safety Data

• Hazardous Substances Data: 42057-01-2(Hazardous Substances Data)

Upstream product

• 872-31-1 3-Bromothiophene 
• 106-44-5 p-cresol 

Downstream Products

• 866824-52-4 3-(p-tolyloxy)-2,5-dibromothiophene 
• 866824-50-2 4-(p-tolyloxy)-2-(4-(p-tolyloxy)thiophen-2-yl)thiophene 
• 866824-53-5 4-(p-tolyloxy)-2-bromothiophene 
• 81028-66-2 3-(p-tolyloxy)thiophene-2-carboxylic acid 

Relevant articles and documents

Application of Regioselective Thiophene Lithiation to the Synthesis of Thiophene Analogues of Xanthones and Thioxanthones

Treatment of 3-(p-tolyloxy)thiophene (3) with phenyllithium followed by carbonation with CO2 was found to be a convenient procedure for the preparation of the thiophene-2-carboxylic acid 4, which was cyclized to 5 with PPE.Treatment of 3 with butyllithium followed by carbonation gave the thiophene-2,5-dicarboxylic acid 8 which was cyclized to 9.Alkaline permanganate oxidation of 4 gave the diacid 10, which was cyclized to the tricyclic acid 11.Similar lithiation reactions were observed with additional 3-(aryloxy)thiophenes and with 3-(arylthio)thiophenes, and xanthone analogues were prepared from the resulting intermediates.