42074-46-4Relevant articles and documents
Programmed synthesis of arylthiazoles through sequential C-H couplings
Tani, Satoshi,Uehara, Takahiro N.,Yamaguchi, Junichiro,Itami, Kenichiro
, p. 123 - 135 (2014/01/06)
A programmed synthesis of privileged arylthiazoles via sequential C-H couplings catalyzed by palladium or nickel catalysts has been accomplished. This versatile protocol can supply all possible arylthiazole substitution patterns (2-aryl, 4-aryl, 5-aryl, 2
Generation and reactions of heteroaromatic lithium compounds by using in-line mixer in a continuous flow microreactor system at mild conditions
Liu, Binjie,Fan, Yong,Lv, Xiaoming,Liu, Xiaofeng,Yang, Yongtai,Jia, Yu
, p. 133 - 137 (2013/03/13)
A lithium-halogen exchange reaction procedure was applied to introduce electrophilic substituents to the heteroaromatics, which exhibited potential in the syntheses of pharmaceutical intermediates. In this contribution, generation and reactions of heteroa
Optimized S-trityl-l-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models
Good, James A. D.,Wang, Fang,Rath, Oliver,Kaan, Hung Yi Kristal,Talapatra, Sandeep K.,Podgórski, Dawid,MacKay, Simon P.,Kozielski, Frank
supporting information, p. 1878 - 1893 (2013/05/08)
The mitotic kinesin Eg5 is critical for the assembly of the mitotic spindle and is a promising chemotherapy target. Previously, we identified S-trityl-l-cysteine as a selective inhibitor of Eg5 and developed triphenylbutanamine analogues with improved pot
Palladium-catalyzed arylation at C-H and C-C bonds of masked thiazole derivatives
Furukawa, Hirotoshi,Matsumura, Suguru,Sugie, Atsushi,Monguchi, Daiki,Mori, Atsunori
scheme or table, p. 303 - 309 (2009/12/03)
The differently substituted 2,5-diarylthiazole derivatives are synthesized via palladium catalyzed sequential C-H arylation at the 5-position and C-C bond activation at the 2-positon with masked thiazole.
