420786-53-4 Usage
Description
(4-HYDROXYPHENYL)(PIPERIDIN-4-YL)METHANONE is a chemical compound that features a piperidine ring attached to a ketone group and a hydroxyphenyl group. It has potential pharmaceutical applications due to its structural features, which are associated with various biological activities. The piperidine ring is a common structural motif in many pharmaceutical compounds and is known for its diverse range of pharmacological activities, including as central nervous system stimulants and analgesics. The hydroxyphenyl group has antioxidant and anti-inflammatory properties, making (4-HYDROXYPHENYL)(PIPERIDIN-4-YL)METHANONE a promising candidate for drug discovery and development for various medical conditions.
Uses
Used in Pharmaceutical Industry:
(4-HYDROXYPHENYL)(PIPERIDIN-4-YL)METHANONE is used as a potential pharmaceutical compound for its diverse range of pharmacological activities. The piperidine ring contributes to its potential as a central nervous system stimulant and analgesic, while the hydroxyphenyl group provides antioxidant and anti-inflammatory properties. This makes it a candidate for drug discovery and development for various medical conditions.
However, it is important to note that the provided materials do not specify particular applications or industries for (4-HYDROXYPHENYL)(PIPERIDIN-4-YL)METHANONE. (4-HYDROXYPHENYL)(PIPERIDIN-4-YL)METHANONE's potential uses are inferred from its structural features and associated biological activities. Further research and testing would be necessary to fully understand its pharmacological potential and safety profile before it can be applied in specific industries or for specific uses.
Check Digit Verification of cas no
The CAS Registry Mumber 420786-53-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,0,7,8 and 6 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 420786-53:
(8*4)+(7*2)+(6*0)+(5*7)+(4*8)+(3*6)+(2*5)+(1*3)=144
144 % 10 = 4
So 420786-53-4 is a valid CAS Registry Number.
420786-53-4Relevant articles and documents
Structural and Functional Study of the Klebsiella pneumoniae VapBC Toxin-Antitoxin System, including the Development of an Inhibitor That Activates VapC
Kang, Sung-Min,Jin, Chenglong,Kim, Do-Hee,Lee, Yuno,Lee, Bong-Jin
supporting information, p. 13669 - 13679 (2020/12/02)
Klebsiella pneumoniae is one of the most critical opportunistic pathogens. TA systems are promising drug targets because they are related to the survival of bacterial pathogens. However, structural information on TA systems in K. pneumoniae remains lacking; therefore, it is necessary to explore this information for the development of antibacterial agents. Here, we present the first crystal structure of the VapBC complex from K. pneumoniae at a resolution of 2.00 ?. We determined the toxin inhibitory mechanism of the VapB antitoxin through an Mg2+ switch, in which Mg2+ is displaced by R79 of VapB. This inhibitory mechanism of the active site is a novel finding and the first to be identified in a bacterial TA system. Furthermore, inhibitors, including peptides and small molecules, that activate the VapC toxin were discovered and investigated. These inhibitors can act as antimicrobial agents by disrupting the VapBC complex and activating VapC. Our comprehensive investigation of the K. pneumoniae VapBC system will help elucidate an unsolved conundrum in VapBC systems and develop potential antimicrobial agents.
