420799-34-4Relevant academic research and scientific papers
Copper(II) and uranyl(II) complexes with acylthiosemicarbazide: Synthesis, characterization, antibacterial activity and effects on the growth of promyelocytic leukemia cells HL-60
Angelusiu, Madalina Veronica,Almajan, Gabriela Laura,Rosu, Tudor,Negoiu, Maria,Almajan, Eva-Ruxandra,Roy, Jenny
, p. 3323 - 3329 (2009)
New chelates of N1-[4-(4-X-phenylsulfonyl)benzoyl]-N4-butyl-thiosemicarbazide (X = H, Cl, Br) with Cu2+ and UO22+ have been prepared and characterized by analytical and physico-chemical techniques such as magnetic susceptibility measurements, elemental and thermal analyses, electronic, ESR and IR spectral studies. Room temperature ESR spectra of Cu(II) complexes yield {g} values characteristic of distorted octahedral and pseudo-tetrahedral geometry. Infrared spectra indicate that complexes contain six-coordinate uranium atom with the ligand atoms arranged in an equatorial plane around the linear uranyl group. Effects of these complexes on the growth of human promyelocytic leukemia cells HL-60 and their antibacterial activity (against Staphylococcus epidermidis ATCC 14990, Bacillus subtilis ATCC 6633, Bacillus cereus ATCC 14579, Pseudomonas aeruginosa ATCC 9027 and Escherichia coli ATCC 11775 strains) were studied comparatively with that of free ligands.
Synthesis of new substituted th losemicarbazides and their cyclization to triazole-and thiadiazole derivatives
?aramet, Ioana,Drǎghici, Constantin,Bǎrcutean, Corina,Rǎdulescu, Valeria,Loloiu, Teodora,Banciu, Mircea D.
, p. 139 - 153 (2007/10/03)
Nine new thiosemicarbazides substituted with arylsulfonylbenzoyl groups at N1 and with β-phenylethyl, n-butyl and cyclohexyl groups at N4 were obtained in a four-step synthesis involving nucleophilic addition of corresponding acid hydrazides to isocyanates. Cyclization of β-phenylethyl and n-butyl thiosemicarbazides in NaOH solution afforded the corresponding mercaptotriazoles. Cyclization of β-phenylethyl thiosemicarbazides in concentrated H2SO4 gave rise to substituted aminothiadiazoles bearing an -SO3H group in the para- position of the side-chain phenyl ring, whereas Cyclization of n-butyl thiosemicarbazides conducted in a clean way to the expected substituted aminothiadiazoles. The thiosemicarbazides possessing cyclohexyl substituants proved reluctant to Cyclization both in alkaline and acidic medium, probably due to steric hindrance. All the new compounds - extensively characterised by IR, UV, 1H-NMR and 13C-NMR spectra - will be biologically tested.
