420809-56-9Relevant academic research and scientific papers
Green protocol for synthesis of 1,5-benzodiazepines and 1,5-benzothiazepines in the presence of nanocrystalline aluminum oxide
Hekmatshoar, Rahim,Sadjadi, Sodeh,Shiri, Soudeh,Heravi, Majid M.,Beheshtiha, Yahya S.
experimental part, p. 2549 - 2559 (2009/12/04)
An efficient protocol associated with readily available starting materials, mild conditions, excellent yields, and a broad range of the products in synthetic chemistry was established for synthesis of 1,5-benzodiazepine and 1,5-benzothiazepine derivatives
Synthesis of 1,5-benzothiazepines with microwave irradiation under solvent and catalyst-free conditions
Rahman,Roy,Majee,Hajra
experimental part, p. 178 - 179 (2010/02/28)
Microwave irradiation of a,β-unsaturated ketones (chalcones) and o-aminothiophenol in the absence of solvent and catalyst provides a highly efficient methodology for the synthesis of 1,5-benzothiazepines in moderate to good yields.
'On water' synthesis of 2,4-diaryl-2,3-dihydro-1,5-benzothiazepines catalysed by sodium dodecyl sulfate (SDS)
Sharma, Gaurav,Kumar, Raj,Chakraborti, Asit K.
, p. 4269 - 4271 (2008/09/21)
An efficient synthesis of 1,3-diaryl-2,3-dihydro-1,5-benzothiazepines has been developed by the reaction of various 1,3-diaryl-2-propenones with 2-aminothiophenol in water under neutral conditions catalysed by SDS. Excellent chemoselectivity was observed for substrates possessing halogen atoms or nitro/alkoxy/thioalkyl groups which did not undergo competitive aromatic nucleophilic substitution of the halogen atoms or the nitro group, reduction of the nitro or the α,β-unsaturated carbonyl group, or dealkylation of the alkoxy/thioalkoxy groups.
Magnesium perchlorate as a new and highly efficient catalyst for the synthesis of 2,3-dihydro-1,5-benzothiazepines
Khatik, Gopal L.,Kumar, Raj,Chakraborti, Asit K.
, p. 541 - 546 (2007/12/29)
Commercially available magnesium perchlorate has been found to be a highly efficient catalyst for the reaction of 1,3-diarylprop-2-enones with 2-aminothiophenol leading to the synthesis of 2,3-dihydro-1,5-benzothiazepines in high yields and in short times. Georg Thieme Verlag Stuttgart.
A novel approach to tetrahydrobenzothiazepines from chalcones using o-aminothiophenol
Khanna, Mahavir S.,Kumar, Dalip,Garg, Chandra P.,Kapoor, Ram P.
, p. 333 - 335 (2007/10/02)
Synthesis of 2,3,4,5-tetrahydro-2,4-disubstituted phenyl-5H-benzothiazepines (2a-e) by the in situ reduction of 2,3-dihydro-2,4-disubstituted phenyl-5H-benzothiazepines (3a-e) using o-aminothiophenol in catalytic amount in acidic ethanol is desc
