420820-65-1 Usage
Uses
Used in Pharmaceutical Industry:
2-(3-Bromoazetidin-1-yl)-acetonitrile is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of compounds with significant biological activity. Its unique structure allows for the creation of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(3-Bromoazetidin-1-yl)-acetonitrile serves as an essential intermediate in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds, thereby improving crop yields and quality.
Used in Medicinal Chemistry and Drug Development:
2-(3-Bromoazetidin-1-yl)-acetonitrile is utilized as a versatile compound in medicinal chemistry and drug development due to its capacity to undergo various chemical reactions. This adaptability allows researchers to modify its structure to create new compounds with improved pharmacological properties, such as increased potency, selectivity, and reduced side effects.
It is crucial to handle 2-(3-Bromoazetidin-1-yl)-acetonitrile with care due to its potentially hazardous nature, ensuring safety protocols are followed during its synthesis and application processes.
Check Digit Verification of cas no
The CAS Registry Mumber 420820-65-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,0,8,2 and 0 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 420820-65:
(8*4)+(7*2)+(6*0)+(5*8)+(4*2)+(3*0)+(2*6)+(1*5)=111
111 % 10 = 1
So 420820-65-1 is a valid CAS Registry Number.
420820-65-1Relevant academic research and scientific papers
Synthesis of azetidine derivatives using 1-azabicyclo[1.1.0]butane
Hayashi, Kazuhiko,Hiki, Shinsuke,Kumagai, Toshio,Nagao, Yoshimitsu
, p. 433 - 442 (2007/10/03)
A THF solution of 1-azabicyclo[1.1.0]butane (2), obtained from 2,3-dibromopropylamine hydrobromide (1), was treated with HC1-EtOH, 48% HBr, ClCO2Et, Ts2O, HCO2H-2.7N HCl-MeOH, or Ac2O- 3N HCl to give the corresponding 3-monosubstituted and 1,3-disubstituted azetidine derivatives (3-7). Similar treatment of 2 with AcSH afforded 1-acetyl-3-acetylthioazetidine (8), which was converted to 1-(1,3-thiazolidin-2-yl)azetidine-3-thiol hydrochloride (10). The compound (2) and various bromides were heated to furnish 3-bromoazetidine derivatives (12b,c,e,f) and/or N,N-disubstituted 2,3-dibromopropylamines (13a, c-f). The reaction of 2 with benzoyl peroxide or N-bromosuccinimide gave each corresponding 1,3-disubustituted azetidine derivative (14 or 15).
