420834-29-3

Upstream product

• 420834-16-8 3-(2,2,2-trichloroethoxycarbonyl)-2-cyclohexyl-4-phenyl-5-oxazolidinecarboxylic acid methyl ester 
• 157425-30-4 N-2,2,2-trichloroethoxycarbonyl phenylisoserine methyl ester 
• 132201-32-2 (2R,3S)-3-phenylisoserine hydrochloride 
• 156857-29-3 (4R,4aS,7aS,8S)-4,8-dihydroxy-4,4a,5,6,7,7a,8,9-octahydro-6,6,8-trimethylazulene<5,6-c>furan 
• 420834-18-0 3-(2,2,2-trichloroethoxycarbonyl)-2-cyclohexyl-4-phenyl-5-oxazolidinecarboxylic acid 

Downstream Products

• 420834-47-5 (2R,3S)-3-Amino-2-hydroxy-3-phenyl-propionic acid (4R,4aS,7aS,8S)-8-hydroxy-6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydro-2-oxa-cyclopenta[f]azulen-4-yl ester 

Relevant academic research and scientific papers

Synthesis and Antifeedant Properties of N-Acylphenylisoserinates of Lactarius Sesquiterpenoid Alcohols

The esterification of various sesquiterpenoid alcohols of Lactarius origin with N-benzoyl-[2R,3S]-phenylisoserine (side chain of Taxol), N-acetyl-[2R,3S]-phenylisoserine and N-tert-butoxy-[2R,3S]-phenylisoserine (side chain of Taxotere) produced compounds whose antifeedant properties against storage pests Tribolium confusum, Trogoderma granarium, Sitophylus granarius and Rhizoperta dominica were measured. The introduction of the ester moiety in these molecules, in comparison to original compounds, moderately enhanced their antifeedant activities, as well as changed their selectivity of activity towards the test insects.

Synthesis and cytotoxic properties of N-Boc-phenylisoserinates of sesquiterpenoic alcohols from mushrooms of Lactarius genus, as analogues of Taxotere

Sesquiterpenoic analogues of Taxotere i.e., N-BOC-phenylisoserinates of sesquiterpenoic alcohols, isolated from mushrooms of Lactarius genus, were synthesized. Cytotoxicity of compounds, thus obtained, was evaluated using Vero cells.