420845-41-6Relevant academic research and scientific papers
Synthesis of 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate.
Giner, Jose-Luis,Ferris Jr., William V
, p. 1225 - 1226 (2002)
[reaction: see text] The synthesis of 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate, a biochemical intermediate in the deoxyxylulose pathway of isoprenoid biosynthesis, was accomplished in four steps. Bisphosphorylation of 2-C-methyl-D-erythritol 1,3-dia
Enantiomeric synthesis of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
Narayanasamy, Prabagaran,Crick, Dean C.
, p. 243 - 247 (2011/04/17)
Enantiomerically pure 2-C-methyl-D-erythritol 2,4-cyclodiphosphate 1 (ME-CPP) is synthesized from 1,2-O-isopropylidene-α-D-xylofuranose with facile phosphorylation in good yield. Subsequently, the synthesized enantiomerically pure 1 can be used as a substrate in IspG assays to identify inhibitors that may be developed into antibacterial drug leads. The Japan Institute of Heterocyclic Chemistry.
