42091-89-4

Usage

InChI:InChI=1/C8H12/c1-3-5-7-8-6-4-2/h1,5,7H,4,6,8H2,2H3/b7-5-

Upstream product

• 52517-92-7 1-octyn-4-ol 
• 109-72-8 n-butyllithium 
• 460-12-8 Butadiyne 
• 693-04-9 butyl magnesium bromide 
• 110-62-3 pentanal 
• 18243-59-9 (2-bromoethynyl)trimethylsilane 
• 187874-95-9 (Z)-1-hexenyldi(3-methyl-2-butyl)borane 
• 16538-47-9 (Z)-1-iodohex-1-ene 
• 70277-75-7 lithium acetylide 

Downstream Products

• 1356478-46-0 (Z)-1-phenyldec-5-ene-1,3-diyne 

Relevant academic research and scientific papers

Homo- and heterocoupling of terminal conjugated enynes: One-pot synthesis of alka-1,7-diene-3,5-diynes and alk-1-ene-3,5-diynes via two types of coupling reaction

Conjugated dienediynes and enediynes with definite geometry- have been prepared in a one-pot manner. This protocol involves two types of coupling reaction, a Suzuki-type coupling and either a Hay coupling or a Cadiot-Chodkiewicz coupling. Thus, the copper

Stereoselective syntheses of (E)- and (Z)-1-arylalk-3-en-1-ynes and (E,E)-, (Z,E)-, (E,Z)-, and (Z,Z)-alka-1,5-dien-3-ynes via a one-pot multicomponent coupling reaction

Both 1-arylalk-3-en-1-ynes and alka-1,5-dien-3-ynes have been synthesized under extremely mild reaction conditions in good to high yields via a sequential Suzuki-type and Sonogashira reaction in a one-pot manner. Thus, the protocol involves Cu-mediated cross-coupling reaction of (E)- or (Z)- alkenyldisiamylborane with (trimethylsilyl)ethynyl bromide in the presence of 1M NaOMe and Pd/Cu-catalyzed cross-coupling reaction with aryl or alkenyl iodide in the presence of aqueous n-Bu4NOH. The reaction with aryl iodide is tolerant of a wide variety of functional groups on the aromatic ring and leads to the stereoselective formation of (E)- and (Z)-1-arylalk-3-en-1-ynes. In addition, the reactions with (E)- and (Z)-1-iodoalk-1-enes have accomplished the construction of all possible combinations of geometrical isomers, (E,E)-, (Z,E)-, (E,Z)-, and (Z,Z)-alka-1,5-dien-3-ynes. Georg Thieme Verlag Stuttgart.

A study of the reactions of 1,3-diynes with organo-cuprates and -argentates

1,3-Diynes HCC-CC-R' (1, R'= H or Ph) are converted by cuprates M' (R = alkyl; Y = Cl, Br or R; M'= Li, MgCl or MgBr) into a mixture of C-R'>M' (2) and C-R'>M' (3).When R is n-alkyl, adducts 2 are the major pr