42106-50-3

Basic information

• Product Name: 5-NITRO-2-PIPERIDIN-1-YL-BENZOIC ACID
• Synonyms: 5-nitro-2-(1-piperidinyl)Benzoic acid
• CAS NO: 42106-50-3
• Molecular Formula: C₁₂H₁₄N₂O₄
• Molecular Weight: 250.26
• Mol File: 42106-50-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 455.3°Cat760mmHg
• Flash Point: 229.2°C
• Appearance: /
• Density: 1.344g/cm³
• Vapor Pressure: 4.42E-09mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: 5-NITRO-2-PIPERIDIN-1-YL-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-NITRO-2-PIPERIDIN-1-YL-BENZOIC ACID(42106-50-3)
• EPA Substance Registry System: 5-NITRO-2-PIPERIDIN-1-YL-BENZOIC ACID(42106-50-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 42106-50-3(Hazardous Substances Data)

Usage

General Description

5-NITRO-2-PIPERIDIN-1-YL-BENZOIC ACID is a chemical compound with the molecular formula C14H15N3O4. It is a nitrobenzoic acid derivative containing a piperidine ring, and it is characterized by its nitro group, which gives it its chemical and biological properties. 5-NITRO-2-PIPERIDIN-1-YL-BENZOIC ACID is used in the pharmaceutical industry as a precursor in the synthesis of various drugs and bioactive molecules. It has also been studied for its potential as an antimicrobial and antiparasitic agent. Additionally, it has shown promise in the development of new therapies for certain diseases and conditions. Overall, 5-NITRO-2-PIPERIDIN-1-YL-BENZOIC ACID has a variety of potential applications and properties that make it of interest to researchers and industry professionals alike.

InChI:InChI=1/C12H14N2O4/c15-12(16)10-8-9(14(17)18)4-5-11(10)13-6-2-1-3-7-13/h4-5,8H,1-3,6-7H2,(H,15,16)

Upstream product

• 110-89-4 piperidine 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 445-29-4 o-fluoro-benzoic acid 
• 7304-32-7 2-fluoro-5-nitrobenzoic acid 
• 17417-09-3 2-fluoro-5-nitrobenzonitrile 
• 81215-40-9 2-(1-piperidinyl)-5-nitro-benzoic zcid, methyl ester 
• 474521-55-6 methyl 5-nitro-2-{[(trifluoromethyl)sulfonyl]oxy}benzoate 
• 17302-46-4 methyl 2-hydroxy-5-nitrobenzoate 
• 19555-58-9 8-Nitro-perhydro-pyrrido<1,2-b>benz-1,3-oxazin-6-on 

Downstream Products

• 19555-58-9 8-Nitro-perhydro-pyrrido<1,2-b>benz-1,3-oxazin-6-on 
• 6574-15-8 1-(4-nitrophenyl)piperidine 

Relevant articles and documents

Discovery of novel 2-phenylamino-4-prolylpyrimidine derivatives as TRK/ALK dual inhibitors with promising antitumor effects

In order to explore novel TRK and ALK dual inhibitors, a series of 2-phenylamino-4-prolylpyrimidine derivatives were designed, synthesized and evaluated for their in vitro cytotoxicity and enzymatic activities. Delightfully, most compounds were detected m

Discovery of 4-benzoylpiperidine and 3-(piperidin-4-yl)benzo[d]isoxazole derivatives as potential and selective GlyT1 inhibitors

Regulation of glycine transporter 1 (GlyT1) activity is a currently investigated strategy in drug discovery for schizophrenia. This study developed a series of new 4-benzoylpiperidine derivatives as GlyT1 inhibitors by bioisosteric replacement and mimicking of the pyridine ring of RG1678. Among the 4-benzoylpiperidine derivatives, 23q showed an IC50 of 30 nM. Preliminary optimization of the blood-brain barrier penetration led to the discovery of 3-(piperidin-4-yl)benzo[d]isoxazole derivatives. Both series showed good selectivity over GlyT2, D1, D2, D3, 5-HT1A and 5-HT2A receptors. Moreover, behavioral testing showed 23q (40 mg kg-1, intragastric) can inhibit the hyperlocomotion induced by acute treatment of phencyclidine, and improve the impaired negative and cognitive symptoms in chronic phencyclidine-induced C57BL/6J mice. An interesting finding showed that 3-(piperidin-4-yl)benzo[d]isoxazole was a privileged scaffold of atypical antipsychotic agents but exhibited high selectivity and potency as a GlyT1 inhibitor.

Intramolecular reactions of iminium compounds with carboxylic acids

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