4211-87-4

Usage

Uses

Used in Pharmaceutical Industry:
5-(4-Chlorophenyl)-3-methylisoxazole is used as a pharmaceutical compound for its potential medicinal properties, targeting the treatment of various medical conditions. Its unique structure and properties make it a promising candidate for further investigation and development in the field of medicinal chemistry.
Used in Chemical Research and Synthesis:
In the chemical research industry, 5-(4-Chlorophenyl)-3-methylisoxazole serves as a valuable compound for synthesis and exploration of new chemical entities. Its structure and reactivity can be leveraged to create novel molecules with potential applications in various fields, including materials science and drug discovery.

Upstream product

• 76387-90-1 4-(p-chlorophenyl)-6-methyl-1-phenyl-2(1H)-pyrimidinone 
• 112778-99-1 1-(4-chlorophenyl)-3-(dimethylamino)but-2-en-1-one 
• 196953-02-3 1-(4-chlorophenyl)buta-2,3-dien-1-one 
• 20900-91-8 4-(p-chlorophenyl)-3-buten-2-one oxime 

Relevant academic research and scientific papers

Monohydrochloride Assisted Synthesis of Functionalized Isoxazoles and Pyrazoles from Allenic Ketones: First Synthesis of (Z)-2-Methyl-7H-benzo[b]pyrazolo[5,1-d][1,5]oxazocines

A facile hydrochloride promoted regioselective synthesis of isoxazoles and pyrazoles from 1,2-allenic ketones is reported. The reaction has been scaled up to gram scale. A direct 8-endo dig ring annulations towards the first synthesis of (Z)-2-methyl-7H-b

An efficient synthesis of isoxazoles and pyrazoles under ultrasound irradiation

A series of 5-arylisoxazole and 5-aryl-1H-pyrazole derivatives was synthesized by the reaction of 3-(dimethylamino)-1-arylprop-2-en-1-one with hydroxylamine hydrochloride or hydrazine hydrate under ultrasound irradiation without using any catalyst. This m

Clean and efficient synthesis of isoxazole derivatives in aqueous media

A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild rea

Synthesis of 3-Substituted 5-Arylisoxazoles from α,β-Unsaturated Oximes

The synthesis of 3-substituted 5-arylisoxazoles from oximes of α,β-unsaturated ketones is studied. The formation of the isoxazole derivatives takes place by cyclization of oximes in the presence of iodine and potassium iodide. The presence of isoxazoline

RING TRANSFORMATION REACTION OF 1,4,6-TRISUBSTITUTED 2(1H)-PYRIMIDINONES AND -THIONES WITH HYDROXYLAMINE

1,4,6-Trisubstituted 2(1H)-pyrimidinones (Ia-e) underwent ring transformation with hydroxylamine to afford 3,5-disubstituted isoxazoles (IIa-e) in high yields.On the other hand, 2(1H)-pyrimidinethiones (IIIa, b, f-k) underwent ring transformation to give mainly a new type of N-substituted 2-aminopyrimidine 1-oxides (IVa, b, f-k) as well as isoxazoles.The reaction of pyrimidinium salts (VII, VIII, and IX) with hydroxylamine is also discussed.Keywords: - ring tranformation reaction; hydroxylamine; nucleophilic reaction; 3,5-disubstituted isoxazoles; N-substituted 2-aminopyrimidine 1-oxides; pyrimidinium salts