42123-27-3

Basic information

• Product Name: Tetradehydropodophyllotoxin
• Synonyms: Tetradehydropodophyllotoxin
• CAS NO: 42123-27-3
• Molecular Formula: C₂₂H₁₈O₈
• Molecular Weight: 410.37352
• Mol File: 42123-27-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 286-288 °C (decomp)
• Boiling Point: 638.0±55.0 °C(Predicted)
• Appearance: /
• Density: 1.429±0.06 g/cm3(Predicted)
• PKA: 7.63±0.20(Predicted)
• CAS DataBase Reference: Tetradehydropodophyllotoxin(CAS DataBase Reference)
• NIST Chemistry Reference: Tetradehydropodophyllotoxin(42123-27-3)
• EPA Substance Registry System: Tetradehydropodophyllotoxin(42123-27-3)

Safety Data

• Hazardous Substances Data: 42123-27-3(Hazardous Substances Data)

Usage

Uses

Tetradehydropodophyllotoxin is a aryl-naphthalene lignans that was shown to exhibit anticancer activities.

Upstream product

• 717903-52-1 6-(trimethylsilyl)benzo[d][1,3]dioxol-5-yl triflate 
• 1002130-61-1 8-oxo-9-(3,4,5-trimethoxyphenyl)-6,8-dihydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carbaldehyde 
• 1002130-85-9 9-hydroxymethyl-5-(3,4,5-trimethoxyphenyl)-8H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 1002130-60-0 1-hydroxy-5-(3,4,5-trimethoxyphenyl)-1,3-dihydro-2,7,9-trioxadicyclopenta[a,g]naphthalene-4-carboxylic acid methyl ester 
• 1002130-83-7 C₂₅H₂₃NO₉ 
• 1002130-82-6 3-(N-methoxy-N-methylcarbamoyl)prop-2-ynyl 3-(3,4,5-trimethoxyphenyl)propiolate 
• 112667-57-9 tert-butyldimethylsilyldehydropodophyllotoxin 
• 42123-24-0 dimethyl 4-hydroxy-6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)naphthalene-2,3-dicarboxylate 
• 477-48-5 podophyllotoxone 
• 477-48-5 (5aR,8aS,9R)-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5,8-dione 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 42123-13-7 7-(3,4,5-trimethoxy-phenyl)-7H-[1,3]dioxolo[4,5-f]isobenzofuran-5-one 
• 42202-83-5 α-2-<(1,3-dioxolan-2-yl)-4,5-methylenedioxyphenyl>-3,4,5-trimethoxybenzyl alcohol 
• 2139-43-7 5-bromo-6-(1,3-dioxolan-2-yl)benzo[d][1,3]dioxolane 

Downstream Products

• 1002130-62-2 8-oxo-9-(3,4,5-trimethoxyphenyl)-6,8-dihydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl trifluoromethanesulfonate 
• 6258-41-9 5-(3,4,5-Trimethoxy-phenyl)-8H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 

Relevant articles and documents

Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest

The two new lignans 3α-O-(β-d-glucopyranosyl)desoxypodophyllotoxin (1) and 4-O-(β-d-glucopyranosyl)dehydropodophyllotoxin (2) were isolated from Cleistanthus boivinianus, together with the known lignans deoxypicropodophyllotoxin (3), (±)-β-apopicropodophy

A novel enzymatic dehydrogenation of podophyllotoxin congeners by yeast cells

The biotransformation of aryltetralin lignans to arylnaphthalene lignans in presence of yeast is described. Podophyllotoxone, an oxidation product of podophyllotoxin on incubation with yeast from different sources produced dehydropodophyllotoxin, an important representative of arylnaphthalene lignans.

Efficient Syntheses of 1-Arylnaphthalene Lignan Lactones and Related Compounds from Cyanohydrins

1-Arylnaphthalene lignan lactones were synthesized in good yields from O-(tert-butyldimethylsilyl)cyanohydrins in two steps based on a conjugate addition-aldol reaction, followed by acid-catalyzed closure to form the naphthalene ring. 4-Hydroxy-1-arylnaph