42134-74-7

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 38733-98-1 4-(trifluoromethyl)benzyltriphenylphosphonium bromide 
• 402-50-6 1-trifluoromethyl-4-vinyl-benzene 
• 119757-51-6 1,2-bis(4-(trifluoromethyl)phenyl)ethyne 
• 603-35-0 triphenylphosphine 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 
• 349-95-1 4-(trifluoromethyl)benzylic alcohol 
• 1873-88-7 1,1,1,3,5,5,5-heptamethyltrisiloxan 
• 99578-68-4 diethyl (4-(trifluoromethyl)benzyl)phosphonate 
• 2338-75-2 4-(Trifluoromethyl)phenylacetonitrile 
• 32857-62-8 4-Trifluoromethylphenylacetic acid 
• 42134-68-9 E-2-(4-trifluoromethylphenyl)-3-(4-trifluoromethylphenyl)acrylic acid 
• 939-99-1 4-trifluoromethylbenzyl chloride 
• 98-56-6 4-chlorobenzotrifluoride 

Downstream Products

• 42134-70-3 (Z)-1,2-bis(4-(trifluoromethyl)phenyl)ethene 
• 135733-72-1 C₁₆H₁₀Br₂F₆ 
• 213776-03-5 (R,R)-(+)-1,2-bis(4-trifluoromethylphenyl)ethane-1,2-diol 
• 42134-71-4 1,2-bis(4-(trifluoromethyl)phenyl)ethane 
• 327628-47-7 cis-2,3-bis(4-(trifluoromethyl)phenyl)oxirane 
• 1182735-05-2 [(4S,5S)-4,5-dihydro-4,5-bis[4-(trifluoromethyl)phenyl]isoxazol-3-yl][(3aS,6R,7aR)-tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1,(4H)-yl]methanone 

Relevant academic research and scientific papers

Energy-Transfer-Mediated Photocatalysis by a Bioinspired Organic Perylenephotosensitizer HiBRCP

Energy transfer plays a special role in photocatalysis by utilizing the potential energy of the excited state through indirect excitation, in which a photosensitizer determines the thermodynamic feasibility of the reaction. Bioinspired by the energy-transfer ability of natural product cercosporin, here we developed a green and highly efficient organic photosensitizer HiBRCP (hexaisobutyryl reduced cercosporin) through structural modification of cercosporin. After structural manipulation, its triplet energy was greatly improved, and then, it could markedly promote the efficient geometrical isomerization of alkenes from the E-isomer to the Z-isomer. Moreover, it was also effective for energy-transfer-mediated organometallic catalysis, which allowed realization of the cross-coupling of aryl bromides and carboxylic acids through efficient energy transfer from HiBRCP to nickel complexes. Thus, the study on the relationship between structural manipulation and their photophysical properties provided guidance for further modification of cercosporin, which could be applied to more meaningful and challenging energy-transfer reactions.

AIR-STABLE NI(0)-OLEFIN COMPLEXES AND THEIR USE AS CATALYSTS OR PRECATALYSTS

The present invention relates to air stable, binary Ni(0)-olefin complexes and their use in organic synthesis.

Efficient preparation method of symmetric diarylethene compound

The invention belongs to the technical field of fine chemicals and related chemistry, and provides an efficient preparation method of a symmetric diarylethene compound. The method comprises the following steps: with halomethyl-containing aromatic hydrocarbon and derivatives thereof as raw materials, conducting reacting at 100 DEG C for 12 hours in the presence of a catalyst, alkali, additives andan anhydrous organic solvent so as to obtain the corresponding diarylethene compound with symmetry. The method has the beneficial effects that no transition metal reaction exists, reaction conditionsare mild, operation is simple and convenient, the possibility of industrialization is realized, and the diarylethene compound is obtained at high yield; and the diarylethene compound synthesized by using the method can be further functionalized to obtain various compounds, and is applied to development and research of natural products, functional materials and fine chemicals.

Ni(4?Tbustb)3: A robust 16-electron Ni(0) olefin complex for catalysis

Sixteen-electron Ni(0) complexes bearing trans-stilbene derivative ligands have been shown to display a high degree of stability toward oxidation in the solid state. A structural analysis of a unique family of tris Ni(0) stilbene complexes revealed a remarkable effect of the steric hindrance of the substituents at the para position of the stilbene unit to temperature, oxidation, and degradation in solution. From these analyses, Ni(4?tBustb)3 arose as a long-term air-, bench-. and temperature-stable Ni(0) complex. Importantly, Ni(4?tBustb)3 presents faster kinetic profiles and a broader scope as a Ni(0) source, thus outperforming the previously described Ni(4?CF3stb)3 in a variety of relevant Ni-catalyzed transformations.

Tuning the Selectivity of Palladium Catalysts for Hydroformylation and Semihydrogenation of Alkynes: Experimental and Mechanistic Studies

Here, we describe a selective palladium catalyst system for chemodivergent functionalization of alkynes with syngas. In the presence of an advanced ligand L2 bearing 2-pyridyl substituent as a built-in base, either hydroformylation or semihydrogenation of diverse alkynes occurs with high chemo- and stereoselectivity under comparable conditions. Mechanistic studies, including density functional theory (DFT) calculations, kinetic analysis, and control experiments, revealed that the strength and concentration of acidic cocatalysts play a decisive role in controlling the chemoselectivity. DFT studies disclosed that ligand L2 not only promotes heterolytic activation of hydrogen similar to frustrated Lewis pair (FLP) systems in the hydrogenolysis step for hydroformylation but also suppresses CO coordination to promote semihydrogenation under strong acid conditions. This switchable selectivity provides a strategy to design new catalysts for desired products.

Oxidative Dephosphorylation of Benzylic Phosphonates with Dioxygen Generating Symmetrical trans-Stilbenes

Under a dioxygen atmosphere, benzylphosphonates and related phosphoryl compounds can readily produce the corresponding trans-stilbenes in high yields with high selectivity upon treatment with bases. Various functional groups were tolerable under the reaction conditions.

Selenolate Anion as an Organocatalyst: Reactions and Mechanistic Studies

A new organocatalyst, the selenolate anion [RSe]–, generated from bench-stable and commercially available diphenyl diselenide or from phenyl benzyl selenide (10 mol%) is introduced. Benchmarking is performed in the conversion of benzylic chlorides into trans-stilbenes selectively at room temperature. Mechanistic studies support the intermediacy of the selenolate anion and of 1,2-diphenylethyl phenyl selenide. (Figure presented.).

Direct Conversion of Alcohols into Alkenes by Dehydrogenative Coupling with Hydrazine/Hydrazone Catalyzed by Manganese

We have developed unprecedented methods for the direct transformation of primary alcohols to alkenes in the presence of hydrazine, and for the synthesis of mixed alkenes by the reaction of alcohols with hydrazones. The reactions are catalyzed by a manganese pincer complex and proceed in absence of added base or hydrogen acceptors, liberating dihydrogen, dinitrogen, and water as the only byproducts. The proposed mechanism, based on preparation of proposed intermediates and control experiments, suggests that the transformation occurs through metal–ligand cooperative N?H activation of a hydrazone intermediate.

Tandem Hydrosilylation/o-C-H Silylation of Arylalkynes Catalyzed by Ruthenium Bis(silyl) Aminophosphine Complexes

An unprecedented reaction via consecutive trans-selective hydrosilylation and o-C-H silylation of arylalkynes with hydrosilanes was developed by use of ruthenium complex catalysts Ru{?°3(Si,O,Si)-xantsil}(CO)(PR3) (R = NC4H8 (1-Pyrr), NC5H10 (1-Pip); xantsil = (9,9-dimethylxanthene-4,5-diyl)bis(dimethylsilyl)). This reaction proceeded with gentle heating at 40-60 °C and afforded novel 2,α-bis-silylated (Z)-stilbene or (Z)-styrene derivatives 2 together with an equimolar amount of (E)-/(Z)-arylalkenes as byproducts. The selectivity of the formation of 2 reached a maximum by employing catalyst 1-Pyrr ligated by the less bulky triaminophosphine P(NC4H8)3 and hydrosilane HSiMe(OSiMe3)2 having moderately bulky and electron withdrawing substituents.

Structural requirements for palladium catalyst transfer on a carbon-carbon double bond

Intramolecular transfer of tBu3PPd(0) on a carbon-carbon double bond (C=C) was investigated by using Suzuki-Miyaura coupling reaction of dibromostilbenes with aryl boronic acid or boronic acid esters in the presence of various additi