42138-31-8

Basic information

• Product Name: 4-(4-chlorophenyl)-1-(p-tolylsulphonyl)piperidine-4-carbonitrile
• Synonyms: 4-(4-chlorophenyl)-1-(p-tolylsulphonyl)piperidine-4-carbonitrile;4-(4-Chlorophenyl)-1-[(4-methylphenyl)sulfonyl]-4-piperidinecarbonitrile;4-(4-Chlorophenyl)-1-(p-tolylsulfonyl)piperidine-4-carbonitrile
• CAS NO: 42138-31-8
• Molecular Formula: C₁₉H₁₉ClN₂O₂S
• Molecular Weight: 374.88436
• EINECS: 255-678-2
• Mol File: 42138-31-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 552.6°Cat760mmHg
• Flash Point: 288°C
• Appearance: /
• Density: 1.35g/cm³
• Vapor Pressure: 2.95E-12mmHg at 25°C
• Refractive Index: 1.637
• CAS DataBase Reference: 4-(4-chlorophenyl)-1-(p-tolylsulphonyl)piperidine-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-chlorophenyl)-1-(p-tolylsulphonyl)piperidine-4-carbonitrile(42138-31-8)
• EPA Substance Registry System: 4-(4-chlorophenyl)-1-(p-tolylsulphonyl)piperidine-4-carbonitrile(42138-31-8)

Safety Data

• Hazardous Substances Data: 42138-31-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H19ClN2O2S/c1-15-2-8-18(9-3-15)25(23,24)22-12-10-19(14-21,11-13-22)16-4-6-17(20)7-5-16/h2-9H,10-13H2,1H3

Upstream product

• 42137-88-2 N,N-bis(2-chloroethyl)-p-toluenesulfonamide 
• 140-53-4 p-chlorobenzyl cyanide 

Relevant articles and documents

1-Triarylalkyl-4-phenyl-4-piperidine carboxylic acids and derivatives

The present invention encompasses compounds of the formula STR1 wherein the Alk is straight or branched chain alkylene containing 2-4 carbon atoms; Ar and Ar' are phenyl, Alkyl substituted phenyl wherein the alkyl contains from 1-4 carbon atoms or halo substituted phenyl; Ar" is phenyl, alkyl substituted phenyl wherein the alkyl contains 1-4 carbon atoms, halo substituted phenyl or pyridyl; X is hydrogen, halogen, trifluoromethyl or alkyl having from 1-4 carbon atoms; R is hydrogen, alkyl having from 1-7 carbon atoms, alkenyl having 3-7 carbon atoms, Ar" as herein before defined, or a cation selected from the group consisting of sodium, potassium, ammonium or calcium/2. Compounds of the present invention are potent antidiarrheal agents with little, if any, central nervous system activity.

Synthesis of some 4-(4-chlorophenyl)-l-(3-dialkylaminopropyl)-4-propionylpiperidines

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