42151-36-0Relevant academic research and scientific papers
Factor VIIa inhibitors: Improved pharmacokinetic parameters
Kolesnikov, Aleksandr,Rai, Roopa,Young, Wendy B.,Mordenti, Joyce,Liu, Liang,Torkelson, Steven,Shrader, William D.,Leahy, Ellen M.,Hu, Huiyong,Gjerstad, Erik,Janc, James,Katz, Bradley A.,Sprengeler, Paul A.
, p. 2243 - 2246 (2006)
Efforts to improve the potency and pharmacokinetic properties of small molecule factor VIIa inhibitors are described. Small structural modifications to existing leads allow the modulation of half-life and clearance, potentially making these compounds suitable candidates for drug development.
