42156-25-2Relevant academic research and scientific papers
COPPER-CATALYZED C-H BOND ARYLATION
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Page/Page column 7; 22-23, (2009/04/24)
The present invention is a one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using a combination of aryl halides, a substrate, and a copper salt as catalyst. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores and explosives.
A general method for copper-catalyzed arylation of arene C-H bonds
Do, Hien-Quang,Khan, Rana M. Kashif,Daugulis, Olafs
supporting information; experimental part, p. 15185 - 15192 (2009/03/12)
A general method for copper-catalyzed arylation of sp2 C-H bonds with pKa's below 35 has been developed. The method employs aryl halide as the coupling partner, lithium alkoxide or K3PO4 base, and DMF, DMPU, or mixed DMF/xylenes solvent. A variety of electron-rich and electron-poor heterocycles such as azoles, caffeine, thiophenes, benzofuran, pyridine oxides, pyridazine, and pyrimidine can be arylated. Furthermore, electron-poor arenes possessing at least two electron-withdrawing groups on a benzene ring can also be arylated. Two arylcopper-phenanthroline complex intermediates were independently synthesized.
Copper-catalyzed arylation of heterocycle C-H bonds
Do, Hien-Quang,Daugulis, Olafs
, p. 12404 - 12405 (2008/09/17)
A new method for the direct, copper-catalyzed arylation of heterocycle C-H bonds by aryl halides has been developed. In addition to electron-rich five-membered heterocycles, electron-poor pyridine oxides can also be arylated. The best results are obtained by using a combination of lithium tert-butoxide base, aryl iodide coupling partner, and copper iodide catalyst. Copyright
