421579-68-2

Upstream product

• 102191-92-4 tert-butyldimethylsiloxyacetaldehyde 
• 59983-39-0 (S)-1-amino-2-(methoxymethyl)pyrrolidine 

Downstream Products

• 1053699-90-3 [(1R,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-[1,3]dioxolan-2-yl-1-phenethyl-butyl]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-carbamic acid methyl ester 
• 1026076-65-2 {(R)-1-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-3-phenyl-propyl]-pentyl}-((S)-2-methoxymethyl-pyrrolidin-1-yl)-carbamic acid methyl ester 
• 473808-89-8 [(1R,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-[1,3]dioxolan-2-yl-1-phenethyl-butyl]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine 

Relevant academic research and scientific papers

A short diastereo- and enantioselective synthesis of cis-4,5-disubstituted oxazolidin-2-ones

The asymmetric synthesis of cis-4,5-disubstituted oxazolidin-2-ones is described. Following a four step reaction sequence of α-alkylation, 1,2-addition with subsequent carbamate protection, cyclization and concluding with cleavage of the auxiliary the title compounds are obtained in moderate yields and in excellent diastereo- and enantiomeric excesses (de = 88 - > 96%, ee > 96%).