421580-53-2

Basic information

• Product Name: N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE
• Synonyms: N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE;N-[2-(5-CHLORO-2-METHOXY-PHENYLAMINO)-4'-METHYL-[4,5']BITHIAZOLYL-2'-YL]-BENZAMIDE;N-[5-[2-(5-Chloro-2-methoxy-anilino)thiazol-4-yl]-4-methyl-thiazol-2-yl]benzamide
• CAS NO: 421580-53-2
• Molecular Formula: C21H17ClN4O2S2
• Molecular Weight: 456.97
• Mol File: 421580-53-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE(421580-53-2)
• EPA Substance Registry System: N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE(421580-53-2)

Safety Data

• Hazardous Substances Data: 421580-53-2(Hazardous Substances Data)

Usage

Description

N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE, also known as Corr-4a, is a cell-permeable bisaminomethylbithiazole compound that has been reported to rescue and correct the folding defect of the CFTR ΔF508 mutant via direct interaction. N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE promotes proper trafficking, glycosylation, and surface expression in both transfected cells and primary airway epithelial cells from ΔF508-homozygous patients. Corr-4a has been shown to enhance the folding efficiency of both ΔF508 and wild-type CFTR, delay the ER-associated degradation of the core-glycosylated ΔF508, and increase the stability of low-temperature rescued ΔF508 mutant on the plasma membrane. It is more effective than VRT-325/CFcor-325 in restoring forskolin-stimulated CFTR activity in FRT and A549 ΔF508-CFTR transfectants and does not affect mutant CFTR channel gating activity.

Uses

Used in Pharmaceutical Industry:
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE is used as a therapeutic agent for the treatment of cystic fibrosis, specifically targeting the CFTR ΔF508 mutation. It works by rescuing and correcting the folding defect of the CFTR ΔF508 mutant, promoting proper trafficking, glycosylation, and surface expression in cells. This leads to enhanced folding efficiency, delayed ER-associated degradation, and increased stability of the mutant protein on the plasma membrane, ultimately restoring forskolin-stimulated CFTR activity in affected cells.