42167-65-7

Usage

Uses

Used in Drug Delivery Systems:
2',3'-di-O-acetylguanosine is used as a component in drug delivery systems for its potential to improve the solubility and stability of therapeutic agents. Its chemical properties allow for the development of novel drug delivery platforms that can enhance the bioavailability and therapeutic outcomes of various medications.
Used in Synthesis of Nucleoside Analogs:
2',3'-di-O-acetylguanosine is used as a building block in the synthesis of nucleoside analogs, which are important in the development of new antiviral and anticancer drugs. Its unique structure provides a foundation for the creation of novel compounds with potential therapeutic applications.
Used in Antiviral Applications:
2',3'-di-O-acetylguanosine is used as an antiviral agent due to its ability to inhibit viral replication and reduce the severity of viral infections. Its antiviral properties make it a valuable candidate for further research and development in the field of antiviral therapeutics.
Used in Immunosuppressive Applications:
2',3'-di-O-acetylguanosine is used as an immunosuppressive agent, helping to modulate the immune response and prevent overactive immune reactions. This makes it a potential candidate for the treatment of autoimmune diseases and conditions requiring immunosuppression.
Used in Anti-inflammatory Applications:
2',3'-di-O-acetylguanosine is used as an anti-inflammatory agent, reducing inflammation and alleviating symptoms associated with inflammatory conditions. Its anti-inflammatory effects contribute to its potential use in the treatment of various inflammatory diseases.

Upstream product

• 6979-94-8 2',3',5'-tri-O-acetyl-guanosine 

Downstream Products

• 81570-51-6 C₁₀H₁₂N₅O₁₃P₃S^(4-) 

Relevant academic research and scientific papers

A simple enzymatic preparation of 2',3'-di-O-acetylnucleosides through a lipase catalyzed alcoholysis

Several 2',3'-di-O-acetylnucleosides (2a-d) were obtained regioselectively through a Candida antarctica B lipase catalyzed alcoholysis.

COMPOUND HAVING INHIBITORY ACTIVITY ON A RHO-GTPASE CELL PROTEIN, A PROCESS FOR OBTAINING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISION THEREOF AND A METHOD FOR THE TREATMENT OF A RHO-GTPASE CELL PROTEIN-MEDIATED CONDITION

The present invention relates to a compound having inhibitory activity on a Rho-GTPase cell protein, the compound having the formula I (Formula I ) wherein A is selected from N and N-H, R1 is selected from H and NHR3, R2 is selected from NHR4, OR4, O and halogen, R3 is selected from H and -COR5, R4 is selected from H, a C1-C6 alkyl and a substituted or unsubstituted phenyl, R5 is selected from a C1-C12 alkyl and a substituted or unsubstituted phenyl, R6 is selected from H, -COR5, -CO2R5, -PR7R8 and -PR7R8OPR7R8R8R7, R7 is selected from O and S, R8 is selected from H, OR4 and OSATE (-OCH2CH2SCOR5), and wherein each represents a single bond or a double bond, provided that when one of them is a double bond the other one is a single bond, and pharmaceutically acceptable salts and derivatives thereof. In particular, the compounds of the invention may be used as antitumor agents the action of which interfere with the signaling pathways normally involved in tumor development processes. The invention also relates to processes for obtaining of compounds having inhibitory activity of a Rho- GTPase cell protein, to the pharmaceutical compositions thereof and to the therapeutic methods comprising the use of said compounds and compositions.

ENZYMATIC REGIOSELECTIVE DEACYLATION OF 2',3',5'-TRI-O-ACYLRIBONUCLEOSIDES: ENZYMATIC SYNTHESIS OF 2'3'-DI-O-ACYLRIBONUCLEOSIDES

A simple and convenient method was developed for the synthesis of 2',3'-di-O-acetylribonucleoside in good yields by the regioselective enzymatic hydrolysis at the primary hydroxyl group of 2',3',5'-tri-O-acetylribonucleosides.