42167-65-7 Usage
Description
2',3'-di-O-acetylguanosine is a nucleoside derivative of guanosine, a component of RNA, with two acetyl groups attached at the 2' and 3' positions of the sugar ring. This chemical modification results in altered solubility, stability, and biological activity compared to the parent compound. It is a natural product found in certain microorganisms and has been identified as a minor component in the urine of cancer patients. 2',3'-di-O-acetylguanosine has been studied for its potential applications in drug delivery and as a building block for the synthesis of nucleoside analogs. Additionally, it has been shown to exhibit antiviral, immunosuppressive, and anti-inflammatory effects, making it a molecule of interest for further research in medical and pharmaceutical applications.
Uses
Used in Drug Delivery Systems:
2',3'-di-O-acetylguanosine is used as a component in drug delivery systems for its potential to improve the solubility and stability of therapeutic agents. Its chemical properties allow for the development of novel drug delivery platforms that can enhance the bioavailability and therapeutic outcomes of various medications.
Used in Synthesis of Nucleoside Analogs:
2',3'-di-O-acetylguanosine is used as a building block in the synthesis of nucleoside analogs, which are important in the development of new antiviral and anticancer drugs. Its unique structure provides a foundation for the creation of novel compounds with potential therapeutic applications.
Used in Antiviral Applications:
2',3'-di-O-acetylguanosine is used as an antiviral agent due to its ability to inhibit viral replication and reduce the severity of viral infections. Its antiviral properties make it a valuable candidate for further research and development in the field of antiviral therapeutics.
Used in Immunosuppressive Applications:
2',3'-di-O-acetylguanosine is used as an immunosuppressive agent, helping to modulate the immune response and prevent overactive immune reactions. This makes it a potential candidate for the treatment of autoimmune diseases and conditions requiring immunosuppression.
Used in Anti-inflammatory Applications:
2',3'-di-O-acetylguanosine is used as an anti-inflammatory agent, reducing inflammation and alleviating symptoms associated with inflammatory conditions. Its anti-inflammatory effects contribute to its potential use in the treatment of various inflammatory diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 42167-65-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,1,6 and 7 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 42167-65:
(7*4)+(6*2)+(5*1)+(4*6)+(3*7)+(2*6)+(1*5)=107
107 % 10 = 7
So 42167-65-7 is a valid CAS Registry Number.
42167-65-7Relevant articles and documents
A simple enzymatic preparation of 2',3'-di-O-acetylnucleosides through a lipase catalyzed alcoholysis
Zinni, Alejandra,Schmidt, Alejandro,Gallo, Mariana,Iglesias, Luis,Iribarren, Adolfo
, p. 533 - 534 (2000)
Several 2',3'-di-O-acetylnucleosides (2a-d) were obtained regioselectively through a Candida antarctica B lipase catalyzed alcoholysis.
ENZYMATIC REGIOSELECTIVE DEACYLATION OF 2',3',5'-TRI-O-ACYLRIBONUCLEOSIDES: ENZYMATIC SYNTHESIS OF 2'3'-DI-O-ACYLRIBONUCLEOSIDES
Singh, Haribansh K.,Cote, Gregory L.,Sikorski, R. Steven
, p. 5201 - 5204 (2007/10/02)
A simple and convenient method was developed for the synthesis of 2',3'-di-O-acetylribonucleoside in good yields by the regioselective enzymatic hydrolysis at the primary hydroxyl group of 2',3',5'-tri-O-acetylribonucleosides.
