42171-16-4

Upstream product

• 59104-31-3 N,N'-bis(3,5-dimethylphenyl)thiourea 

Downstream Products

• 55425-12-2 3-(3,5-dimethyl-phenyl)-2-(3,5-dimethyl-phenylimino)-1,1-dioxo-1λ⁶-thiazolidin-4-one 
• 42067-15-2 N-tert.-Butyl-N',N''-bis-(3,5-dimethylphenyl)-guanidin 
• 56383-56-3 3-(3,5-dimethyl-phenyl)-2-(3,5-dimethyl-phenylimino)-6-methylsulfanyl-2,3-dihydro-[1,3]thiazin-4-one 
• 42067-07-2 3-tert.-Butyl-1,2-bis-(3,5-dimethylphenyl)-3-hydroxyguanidin 

Relevant academic research and scientific papers

Metal-free access of bulky: N, N ′-diarylcarbodiimides and their reduction: Bulky N, N ′-diarylformamidines

A metal-free synthesis of symmetrical and unsymmetrical bulky N,N′-diaryl carbodiimides from the dehydrosulfurisation of their corresponding N,N′-diarylthiourea with 4-dimethylaminopyridine (DMAP) and iodine under mild reaction conditions with moderate to excellent yields has been established. In the literature, the classical method of dehydrosulfurisation of bulky N,N′-diarylthiourea to N,N′-diarylcarbodiimide has been reported using toxic metal oxide (HgO) and magnesium sulphate (MgSO4) under harsh reaction conditions. Furthermore, easy access to 1,3-disubstituted symmetric and unsymmetrical N,N′-diaryl formamidines involving the reaction of symmetrical and unsymmetrical N,N′-diaryl carbodiimides with sodium borohydride is described. The widely used method for the preparation of bulky N,N′-diaryl formamidines is the treatment of primary amines with triethylorthoformate in the presence of acid under high temperature reaction conditions.