42185-06-8

Basic information

• Product Name: 3-methylmorpholine
• Synonyms: 3-methylmorpholine;3-MethylMorpholine hcl h2o;Morpholine, 3-methyl-
• CAS NO: 42185-06-8
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101.15
• Product Categories: pharmacetical;API intermediates;Heterocycles
• Mol File: 42185-06-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 137.1 °C at 760 mmHg
• Flash Point: 41.3 °C
• Appearance: /
• Density: 0.891 g/cm³
• Vapor Pressure: 7.14mmHg at 25°C
• Refractive Index: 1.409
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.03±0.40(Predicted)
• CAS DataBase Reference: 3-methylmorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methylmorpholine(42185-06-8)
• EPA Substance Registry System: 3-methylmorpholine(42185-06-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• Hazardous Substances Data: 42185-06-8(Hazardous Substances Data)

Usage

General Description

3-Methylmorpholine is a heterocyclic organic compound with the chemical formula C5H11NO. It is a colorless liquid with a faint amine odor and is soluble in water. It is commonly used as a solvent, particularly in the pharmaceutical and chemical industries. 3-methylmorpholine is also used as a raw material in the production of a variety of chemicals, including pesticides, dyes, and pharmaceuticals. It is known to be a mild base and can react with acids to form salts. The compound is considered to be relatively low in toxicity, but exposure to high concentrations can cause irritation to the eyes, skin, and respiratory system.

InChI:InChI=1/C5H11NO/c1-5-4-7-3-2-6-5/h5-6H,2-4H2,1H3

Upstream product

• 55265-78-6 1-(2-Amino-ethoxy)-propan-2-ol 
• 119907-19-6 2-chloro-N-(1-hydroxypropan-2-yl)acetamide 
• 65922-85-2 5-methylmorpholin-3-one 
• 1268866-46-1 4-(4-methoxybenzyl)-3-methylmorpholine 
• 1268866-44-9 4-(4-methoxybenzyl)-5-methylmorpholin-3-one 
• 1268866-42-7 N-(4-methoxybenzyl)-2-bromo-N-(1-hydroxypropan-2-yl)acetamide 

Downstream Products

• 38123-18-1 Rifamycin-B-(2-methyl-morpholid) 
• 1268866-48-3 methyl 3-(3-methylmorpholino)-2-phenylquinoxaline-6-carboxylate 
• 1268863-29-1 3-(3-methylmorpholino)-2-phenylquinoxaline-6-carboxylic acid 
• 1305270-50-1 1-{4-[(3-methylmorpholin-4-yl)methyl]phenyl}-3-(morpholin-4-ylcarbonyl)-1,4-dihydrothichromeno[4,3-c]pyrazole 5,5-dioxide 
• 1352065-28-1 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-((S)-1-(3-methylmorpholino)butan-2-yl)-2-oxopiperidin-3-yl)acetic acid 
• 1346681-94-4 benzyl (3R)-3-methylmorpholine-4-carboxylate 
• 1346681-95-5 (3S)-4-(3-mesitylpropanoyl)-3-methyl morpholine 
• 1215528-41-8 benzyl 3-methylmorpholine-4-carboxylate 
• 1041173-20-9 3-methyl-4-[(4-methylphenyl)sulfonyl]morpholine 
• 350595-57-2 (S)-3-methylmorpholine 
• 74572-04-6 (3R)-3-methylmorpholine 

Relevant articles and documents

Ruthenium-Catalyzed Amination of Secondary Alcohols Using Borrowing Hydrogen Methodology

A new ruthenium complex catalyzes the amination of primary and secondary alcohols and the regioselective mono- and sequential diamination of diols via the borrowing hydrogen pathway. Several variations on new intra- and intermolecular cyclizations of aminoalcohols, diols, and diamines lead to heterocyclic ring systems.

Catalytic asymmetric synthesis of substituted morpholines and piperazines

Under two conditions: Hydroamination catalyzed by group 4 metals is featured in the modular and enantioselective synthesis of 3-substituted morpholines and the diastereoselective synthesis of 2,5-substituted piperazines. Copyright