42185-06-8

Basic information

• Product Name: 3-methylmorpholine
• Synonyms: 3-methylmorpholine;3-MethylMorpholine hcl h2o;Morpholine, 3-methyl-
• CAS NO: 42185-06-8
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101.15
• Product Categories: pharmacetical;API intermediates;Heterocycles
• Mol File: 42185-06-8.mol

Chemical Properties

• Boiling Point: 137.1 °C at 760 mmHg
• Flash Point: 41.3 °C
• Appearance: /
• Density: 0.891 g/cm³
• Vapor Pressure: 7.14mmHg at 25°C
• Refractive Index: 1.409
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.03±0.40(Predicted)
• CAS DataBase Reference: 3-methylmorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methylmorpholine(42185-06-8)
• EPA Substance Registry System: 3-methylmorpholine(42185-06-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• Hazardous Substances Data: 42185-06-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Chemical Industries:
3-Methylmorpholine is utilized as a solvent in the pharmaceutical and chemical industries, leveraging its solubility and mild basicity to facilitate various chemical reactions and processes.
Used in Chemical Production:
It serves as a raw material in the synthesis of a diverse range of chemicals, including pesticides, dyes, and pharmaceuticals, contributing to the development of these products by enabling specific chemical transformations.
Used in the Production of Pesticides:
3-Methylmorpholine is used as a component in the manufacturing process of certain pesticides, where its chemical properties may enhance the effectiveness or stability of the final product.
Used in the Production of Dyes:
In the dye industry, 3-methylmorpholine is employed in the creation of various dyes, potentially improving their colorfastness or application properties.
Used in the Production of Pharmaceuticals:
As a precursor in pharmaceutical manufacturing, 3-methylmorpholine plays a crucial role in the synthesis of active pharmaceutical ingredients, contributing to the development of new medications and therapies.

InChI:InChI=1/C5H11NO/c1-5-4-7-3-2-6-5/h5-6H,2-4H2,1H3

Upstream product

• 119907-19-6 2-chloro-N-(1-hydroxypropan-2-yl)acetamide 
• 55265-78-6 1-(2-Amino-ethoxy)-propan-2-ol 
• 65922-85-2 5-methylmorpholin-3-one 
• 1268866-46-1 4-(4-methoxybenzyl)-3-methylmorpholine 
• 1268866-44-9 4-(4-methoxybenzyl)-5-methylmorpholin-3-one 
• 1268866-42-7 N-(4-methoxybenzyl)-2-bromo-N-(1-hydroxypropan-2-yl)acetamide 

Downstream Products

• 1268866-48-3 methyl 3-(3-methylmorpholino)-2-phenylquinoxaline-6-carboxylate 
• 1268863-29-1 3-(3-methylmorpholino)-2-phenylquinoxaline-6-carboxylic acid 
• 1041173-20-9 3-methyl-4-[(4-methylphenyl)sulfonyl]morpholine 
• 1427474-57-4 4-(6-(benzyloxy)quinolin-3-yl)-3-methylmorpholine 
• 1438397-95-5 (R)-3-methyl-4-tosylmorpholine 
• 74572-04-6 (3R)-3-methylmorpholine 
• 1360882-70-7 3-(4-methoxyphenyl)-3-(4-(2-hydroxyethoxy)phenyl)-6-(3-methylmorpholino)-11-fluoro-13,13-dimethyl-3H,13H-indeno[2,1-f]naphtho[1,2-b]pyran 

Relevant articles and documents

Ruthenium-Catalyzed Amination of Secondary Alcohols Using Borrowing Hydrogen Methodology

A new ruthenium complex catalyzes the amination of primary and secondary alcohols and the regioselective mono- and sequential diamination of diols via the borrowing hydrogen pathway. Several variations on new intra- and intermolecular cyclizations of aminoalcohols, diols, and diamines lead to heterocyclic ring systems.

A concise and efficient synthesis of substituted morpholines

A simple and efficient method has been developed for the synthesis of substituted morpholines by a sequence of coupling, cyclization, and reduction reactions of easily available amino alcohols and α-halo acid chlorides. Various mono-, di-, and trisubstituted morpholines, spiro morpholines, and ring-fused morpholines, as well as morpholine homologues, were synthesized in good to excellent yields by a single methodology under similar reaction conditions. The method was also used in a multigram synthesis of (3S)-3-methylmorpholine.

Catalytic asymmetric synthesis of substituted morpholines and piperazines

Under two conditions: Hydroamination catalyzed by group 4 metals is featured in the modular and enantioselective synthesis of 3-substituted morpholines and the diastereoselective synthesis of 2,5-substituted piperazines. Copyright

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.