42185-95-5Relevant academic research and scientific papers
Stereoselective synthesis of (-)-α-conhydrine
Reddipalli, Gowrisankar,Venkataiah, Mallam,Fadnavis, Nitin W.
experimental part, p. 1778 - 1783 (2012/01/04)
(-)-α-Conhydrine was synthesized from propargyl alcohol in 20% overall yield in nine steps. The key intermediates were obtained via a regioselective epoxide opening, cross-metathesis, tandem hydrogenation and hydrogenolysis, and stereoselective dihydroxyl
Total synthesis and absolute configuration of macrocidin A, a cyclophane tetramic acid natural product
Yoshinari, Tomohiro,Ohmori, Ken,Schrems, Marcus G.,Pfaltz, Andreas,Suzuki, Keisuke
supporting information; experimental part, p. 881 - 885 (2010/05/02)
(Figure Presented) Stereocontrolled access to the cyclophane framework of macrocidin A has been achieved for the first time. The key steps include the iridium-catalyzed asymmetric hydrogenation without fission of the C-I bond, the macrolactam formation by intramolecular ketene trapping, and the Lacey-Dieckmann cyclization for the construction of the tetramic acid ring.
Synthesis of 3-substituted (azido, acylthio, chloro or fluoro)-2,3- dideoxy-D-erythro-pentoses and 3-methyl-3-substituted-2,3-dideoxy-D-erythro- pentoses
Raifeld,Nikitenko,Arshava,Mikerin,Zilberg
, p. 8603 - 8616 (2007/10/02)
The enantioselective synthesis of 3-substituted and 3-methyl-3- substituted 2,3-dideoxy-D-erythro-pentoses from (3R,4R)-1,1-diethoxy-3,4 epoxypentane-5-o1, (3R,4R)-1,1-diethoxy-3,4-epoxy-3-methylpentane-5-o1 and (2R,3R)-2,3-epoxy-5-hexen-1-o1 is reported.
