42205-33-4

Basic information

• Product Name: (E)-ethyl 3-(4-bromophenyl)-2-cyanoacrylate
• Synonyms: (E)-ethyl 3-(4-bromophenyl)-2-cyanoacrylate
• CAS NO: 42205-33-4
• Molecular Weight: 280.121
• Mol File: 42205-33-4.mol
• Article Data: 50

Chemical Properties

• CAS DataBase Reference: (E)-ethyl 3-(4-bromophenyl)-2-cyanoacrylate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-ethyl 3-(4-bromophenyl)-2-cyanoacrylate(42205-33-4)
• EPA Substance Registry System: (E)-ethyl 3-(4-bromophenyl)-2-cyanoacrylate(42205-33-4)

Safety Data

• Hazardous Substances Data: 42205-33-4(Hazardous Substances Data)

Upstream product

• 873-75-6 4-bromobenzenemethanol 
• 105-56-6 ethyl 2-cyanoacetate 
• 64-17-5 ethanol 
• 1122-91-4 4-bromo-benzaldehyde 
• 107-91-5 cyanoacetic acid amide 
• 24856-58-4 1,1-dimethoxy-1-(4-bromophenyl)methane 
• 34421-94-8 4-bromobenzaldehyde diethyl acetal 
• 1187-46-8 ethyl bromocyanoacetate 

Downstream Products

• 77530-11-1 C₂₀H₁₆N₄O₂ 
• 1239897-55-2 5-ethyl 2,3-dimethyl 6-amino-4-(4-bromophenyl)-1-(4-chlorophenyl)-1,4-dihydropyridine-2,3,5-tricarboxylate 
• 1239897-66-5 C₂₇H₂₉BrN₂O₇ 
• 1486487-91-5 4-(4-bromophenyl)-5-cyano-5-ethoxyformacyl-2-methyl-4,5-dihydrooxazole 
• 77198-64-2 2-Amino-4-(4-bromo-phenyl)-5,6,7,8-tetrahydro-naphthalene-1,3-dicarbonitrile 
• 1122-91-4 4-bromo-benzaldehyde 
• 131387-84-3 4-(4-bromophenyl)-2-oxo-3-(1-pyridino)-5-cyano-3,4-trans-1,2,3,4-tetrahydro-6-pyridinolate 
• 77198-40-4 3-Amino-1-(4-bromo-phenyl)-2,4-dicyano-1,2,6,7,8,8a-hexahydro-naphthalene-2-carboxylic acid ethyl ester 
• 105648-23-5 4-(4-Bromo-phenyl)-6-hydroxy-2-thioxo-1,2-dihydro-pyridine-3,5-dicarbonitrile 
• 71471-40-4 2-(4-bromophenyl)succinic acid 
• 158833-80-8 ethyl 2-amino-4-(4-bromophenyl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carboxylate 

Relevant articles and documents

Highly Active Copper(I)-Chalcogenone Catalyzed Knoevenagel Condensation Reaction Using Various Aldehydes and Active Methylene Compounds

First copper(I) chalcogenones catalysed Knoevenagel Condensation reactions have been reported. No illustration of the utilization of this copper-chalcogenone complex class in Knoevenagel Condensation catalysis can be found. Thus, copper(I) bis(benzimidazole-2-chalcogenone) catalysts [Cu(L1)4]+BF4? (1) and [Cu(L2)4]+BF4? (2) (L1 = bis(1-isopropyl-benzimidazole-2-selone)-3-ethyl; L2 = bis(1-isopropyl-benzimidazole-2-thione)-3-ethyl) have been utilized as catalysts in the Knoevenagel Condensation reactions. These copper(I) chalcogenone catalysts have shown high efficiency for the catalytic Knoevenagel Condensation of aryl aldehydes and active methylene compounds. In particular, complex 2, exhibit the best catalytic activities. The scope of the catalytic reactions has been investigated with 22 different molecules. The excellent catalytic activity has been depicted for various types of substrates with either electron-rich or deficient aryl aldehydes. The present investigation features relatively mild reaction conditions with good functional group tolerance and excellent yields. Graphic Abstract: The first copper(I)-chalcogenone complexes catalysed Knoevenagel Condensation reactions?have also been investigated, and revealed the best catalytic activities. [Figure not available: see fulltext.]

Bismuth (III) Triflate: A Mild, Efficient Promoter for the Synthesis of Trisubstituted Alkenes through Knoevenagel Condensation

In this work, smooth efficient and eco-friendly two component coupling method is reported for the synthesis of Knoevenagel Condensation product in presence of Bi(OTf)3 catalyst under solvent free condition. Catalyst has participated in condensation between substituted aldehydes (aromatic and hetero-aromatic) and active methylene compounds (ethyl cyanoacetate, malononitrile and cyanoacetamide) effectively to generate an excellent yield of the product. Bi(OTf)3 catalyst is stable, inexpensive and easily available was used for four times in this reaction without loss of catalytic activity. [Formula Presented]

Cascade reaction synthesis method of 2-(phenylmethylene)malononitrile or derivative thereof

The invention discloses a cascade reaction synthesis method of 2-(phenylmethylene)malononitrile or a derivative thereof. According to the invention, a dendritic acid-alkali catalyst based on cross-linked polystyrene is synthesized, and 2-(phenylmethylene) malononitrile or a derivative thereof is synthesized in batches by successfully applying a cascade reaction into fluid chemistry, so that the method of the invention has advantages of substantially reduced, yield increase and no separation process of a catalyst and a product compared with the traditional test tube reaction.