422280-45-3

Upstream product

• 422280-46-4 (4-{4-chloro-phenyl}-tetrahydro-pyran-4-yl)-acetic acid methyl ester 
• 91-00-9 Benzhydrylamine 

Downstream Products

• 422280-43-1 [4-{4-aminophenyl}tetrahydropyran-4-yl]acetic acid methyl ester trifluoroacetate 

Relevant academic research and scientific papers

Substituted alkanoic acids

The invention is directed to physiologically active compounds of general formula (I): wherein:- represents (i) a saturated 3 to 6 membered carbocycle, optionally substituted by one or more alkyl groups, (ii) indanyl or (iii) a saturated 4 to 6 membered heterocyclic ring; R1 represents R3Z1-Het- or R4N(R5)—C(═O)—NH—Ar1—; L1 represents an —R6—R7— linkage; R2 represents hydrogen, halogen, lower alkyl or lower alkoxy; L2 represents an alkylene linkage; Y is carboxy or an acid bioisostere; and their corresponding N-oxides or prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their corresponding N-oxides or prodrugs. Such compounds have valuable pharmaceutical properties, in particular the ability to regulate the interaction of VCAM-1 and fibronectin with the integrin VLA-4 (α4β1).