4223-94-3

Usage

Uses

Synthesis of pharmaceuticals, dyes, corrosion inhibitors, surfactants, plasticizers, intermediate in the production of agrochemicals and organic high-performance materials

Hazards

Irritation to skin, eyes, and respiratory system upon exposure (handle with caution)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 75-56-9 methyloxirane 
• 66443-73-0 N-allyl-4-methylpiperazine 
• 127-00-4 1-Chloro-2-propanol 
• 19686-73-8 1-bromo-2-propanol 

Downstream Products

• 1224246-46-1 (+/-)-1-[2-(4-chlorophenoxy) propyl]-4-methylpiperazine 
• 1224246-50-7 (+/-)-1-(2-(2,3-dichlorophenoxy)propyl)-4-methylpiperazine 
• 1224246-53-0 (+/-)-1-(2-(2,4-dichlorophenoxy)propyl)-4-methylpiperazine 
• 1224246-56-3 (+/-)-1-(2-(2,5-dichlorophenoxy)propyl)-4-methylpiperazine 
• 1224246-63-2 (+/-)-1-(2-(2,6-dibromophenoxy)propyl)-4-methylpiperazine 
• 1224246-60-9 C₁₄H₂₀Br₂N₂O 

Relevant academic research and scientific papers

Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model

Pyrazolo[3,4-d]pyrimidines are potent protein kinase inhibitors with promising antitumor activity but suboptimal aqueous solubility, consequently worth being further optimized. Herein, we present the one-pot two-step procedure for the synthesis of a set o

Synthesis of piperazino and morpholino derivatives of aryloxypropane with potential analgesic and possible antimigraine activities

Modeling studies demonstrate that aryl piperazines (I), aryloxyalkylamines (II), phenylalkykamines (III) and indolylalkylamines (VI) may interact at 5-HT receptors in a similar manner. Examination of these structures (I-VI) reveals that all possess an aromatic moiety and terminal amine binding sites (Glennon et al., J Med Chem 32(8):1921-1926, 1989). In the present investigation a new series of aryloxyalkylamines (4, 5, 8, and 9) was designed and synthesized, in which the aromatic moiety is a phenyl group substituted at the 2,3-, 2,4-, 2,5-, or 2,6-positions by halogens and the terminal amine is N-methylpiperazine, or morpholine. In addition, the alkyl side chain is ethyl, or substituted ethyl at the α- or β-carbon by a methyl group. The length of the alkyl chain that separates the terminal amine from the ether oxygen atom of the aryloxy group is of major importance, and two-carbon chain appears optimal. The structures of the new compounds were assessed by microanalyses, IR, and NMR. The analgesic activity of selected compounds was performed on experimental animals and proved to be in the range of 85-100% relative to aspirin. Springer Science+Business Media, LLC 2011.

HYDROBORATION D'AMINES ALLYLIQUES. REACTIVITE DES ORGANOBORANES

Hydroboration of differently substituted allylic amines has been studied systematically.It was possible to demonstrate the importance of the hydroboration agent on the formation of aminoboranes.Oxidation of aminoboranes by hydrogen peroxyde in basic medium has ben examined and has led, with good yields, to primary aminoalcohols or a mixture of isomeric aminoalcohols.The influence of steric hindrance on the double bond and that of substitution of the nitrogen atom have been shown.