42230-44-4Relevant academic research and scientific papers
Trans-[Ru(NO)(NH3)P(O-)(OEt)2] 2+: A new and robust NO/HNO-donor in aqueous media
Truzzi, Daniela R.,Franco, Douglas W.
, p. 74 - 79 (2014)
This study describes the synthesis and reactivity in aqueous media of a new potential NO/HNO-donor: trans-[Ru(NO)(NH3)4P(O -)(OEt)2](PF6)2. This compound exhibits a remarkable robustness over a wide range of pH relative to other similar ruthenium phosphorus nitrosyl complexes. At pH 3.0 and 25 °C, trans-[Ru(NO)(NH3)4P(O-)(OEt) 2](PF6)2 decays, yielding free diethyl phosphite with a half-life of 9 days (k = 8.9 × 10-7 s -1). At pH 7.5 and 25 °C, this complex is competitively consumed by diethyl phosphite dissociation (k = 5.15 × 10-5 s -1) and nucleophilic attack at the nitrosyl group (k = 7.25 × 10-5 s-1). Nevertheless, the trans-[Ru(NO)(NH 3)4P(O-)(OEt)2](PF6) 2 exhibits a half-life of 1.5 h (pH 7.5 and 25 °C) for delivering NO/HNO by electrochemical activation at potentials of -0.50 and -0.80 V versus SCE. The NO liberation from trans-[Ru(NO)(NH3)4P(O -)(OEt)2]+ ion occurs with k- NO = 0.24 ± 0.01 s-1, and electrochemical data indicate that k-HNO ? k-NO.
