422312-00-3

Usage

Molecular Structure

Bicyclic compound with a cyclopentane ring fused to an indole ring.

Functional Group

Carboxylic acid group attached to the indole ring at the 5 position.

Potential Use

Intermediate in the synthesis of indole-containing pharmaceuticals and organic compounds.

Biological Activity

May possess biological activity and is of interest in medicinal chemistry.

Research Status

Further research and studies required to determine its full chemical and biological properties.

Upstream product

• 120-92-3 cyclopentanone 
• 5326-27-2 2-hydrazino-benzoic acid 
• 33906-30-8 2-hydrazinobenzoic acid hydrochloride 

Relevant academic research and scientific papers

N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors

Small molecule inhibitors of adipocyte fatty-acid binding protein (A-FABP) have gained renewed interest following the recent publication of pharmacologically beneficial effects of such inhibitors. Despite the potential utility of selective A-FABP inhibito

Indole diterpene synthetic studies: Development of a second-generation synthetic strategy for (+)-nodulisporic acids A and B

(Chemical Equation Presented) A second-generation strategy for construction of (+)-nodulisporic acids A and B based on the development of a new, effective modular indole synthesis exploiting a sequential Stille cross-coupling/Buchwald- Hartwig union/cyclization tactic is disclosed. This strategy evolved due to the considerable acid instability of the C(24) hydroxyl group observed in several advanced intermediates during our first-generation approach.

NOVEL INDOLE DERIVATES AS FABP-4 INHIBITORS

The present invention relates to novel compounds (I) wherein R0, R1, R2, R3, R4, R5, R6, R7, R8, A, B, n, X, and Y are as defined in the description and claims; and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament, which acts on the fatty acid binding protein FABP-4. The present invention relates to novel compounds (I) wherein R0, R1, R2, R3, R4, R5, R6, R7, R8, A, B, n, X, and Y are as defined in the description and claims; and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament, which acts on the fatty acid binding protein FABP-4.