4224-70-8 Usage
Organic Intermediate
6-bromohexanoic acid, also called 6-bromohexanoic acid or 6-bromo-hexanoic acid, is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. 6-Bromohexanoic acid is used in the preparation of N-acylsulfonamides, diarylthioethers and 2-lithio-1,3-dithian. It is widely used as an intermediate in organic synthesis. Here, we introduced a method for making this compound.
Chemical Properties
White to light orange low melting crystals
Uses
Different sources of media describe the Uses of 4224-70-8 differently. You can refer to the following data:
1. Employed in a direct preparation of N-acylsulfonamides on treatment with tosyl isocyanate (189278)1 and alkyl ketones from alkyl iodides and metallic strontium.2
2. 6-Bromohexanoic acid is used in the preparation of N-acylsulfonamides, diarylthioethers and 2-lithio-1,3-dithian. It is widely used as an intermediate in organic synthesis.
3. 6-Bromohexanoic acid was used in the preparation of N-acylsulfonamides on treatment with tosyl isocyanate (189278) and alkyl ketones from alkyl iodides and metallic strontium. It was also used in the synthesis of anionic mitomycin C-dextran conjugate (MMC-D), 2-lithio-1,3-dithian and diaryl thioethers.
Definition
ChEBI: An organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position.
Check Digit Verification of cas no
The CAS Registry Mumber 4224-70-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,2 and 4 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4224-70:
(6*4)+(5*2)+(4*2)+(3*4)+(2*7)+(1*0)=68
68 % 10 = 8
So 4224-70-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H11BrO2/c7-5-3-1-2-4-6(8)9/h1-5H2,(H,8,9)/p-1
4224-70-8Relevant articles and documents
Galli et al.
, p. 8374,8375, 8376, 8378 (1973)
DMF-mediated deprotection of bulky silyl esters under neutral and fluoride-free conditions
Chen, Bo,Sun, Hui-Xia,Qin, Jian-Feng,Wang, Bing
, p. 253 - 255 (2016/01/12)
Bulky TBDPS and TIPS carboxylic esters were efficiently cleaved by a green and mild protocol using only DMF-H2O (20:1) at 70 °C. The neutral conditions tolerate various common acid- and base-labile functionalities, including alkyl and aryl silyl ethers.
A new phenylethyl alkyl amide from the Ambrostoma quadriimpressum Motschulsky
Zhao, Guolei,Yang, Chao,Li, Bing,Xia, Wujiong
supporting information; experimental part, p. 1342 - 1346 (2011/11/14)
A new phenylethyl alkyl amide, (10R)-10-hydroxy-N-phenethyloctadecanamide (1), was isolated from the beetle Ambrostoma quadriimpressum Motschulsky. The structure of the amide was determined by NMR and MS. The absolute configuration of compound 1 was confirmed by an asymmetric total synthesis, which was started from L-glutamic acid. The construction of the aliphatic chain was accomplished by the selective protection of the hydroxy groups and two-time implementation of the Wittig olefination reaction.
