42247-53-0Relevant academic research and scientific papers
Search for new non-nucleoside inhibitors of HIV-1 reverse transcriptase (HIV-1 RT)
Brzezinska, Elzbieta,Glinka, Ryszard
, p. 379 - 386 (2007/10/03)
The derivatives of dibenzoxazocinone, dibenzoxadiazocine, dibenzoxadiazonine, and benzodiazepine systems were synthesized as potential lead compounds for inhibitors of HIV-1 reverse transcriptase. The suggested structures were derived from analysis of the described spatial and physicochemical requirements for HIV-1 RT inhibitors. All of the evaluated compounds (apart from the oxadiazocine derivatives) showed a week inhibitory activity on recombinant HIV-1 RT from Escherichia coli.
