42248-27-1

Usage

InChI:InChI=1/C10H9ClN2O3/c1-6(14)9(13-16)10(15)12-8-4-2-7(11)3-5-8/h2-5,16H,1H3,(H,12,15)/b13-9+

Upstream product

• 101-92-8 4'-Chloroacetoacetanilide 

Downstream Products

• 19183-86-9 3-Benzylimino-2-oximino-buttersaeure-(4-chlor-anilid) 
• 85225-21-4 2-nitroso-3-(p-methoxy)benzylaminocrotonanilide 
• 99378-25-3 5-Methyl-2-vinyl-1H-imidazole-4-carboxylic acid (4-chloro-phenyl)-amide 
• 99378-26-4 N-(4'-Chlorophenyl)-3-allylamino-2-nitroso-2-butenamide 
• 139325-89-6 1,5-Dimethyl-3-oxy-1H-imidazole-4-carboxylic acid (4-chloro-phenyl)-amide 
• 85225-15-6 N-(4-chlorophenyl)-3-methylamino-2-nitroso-2-butenamide 
• 77049-32-2 5-Methyl-2-phenyl-1H-imidazole-4-carboxylic acid (4-chloro-phenyl)-amide 
• 77335-94-5 5-Methyl-2-(4-nitro-phenyl)-1H-imidazole-4-carboxylic acid (4-chloro-phenyl)-amide 
• 19189-29-8 2-hydroximino-3-(E)-methylimino-(p-chloro)crotonanilide 
• 15313-45-8 (4-chlorophenyl)carbamoyl cyanide 
• 103207-61-0 3,5-dimethyl-pyrrole-2,4-dicarboxylic acid bis-(4-chloro-anilide) 

Relevant academic research and scientific papers

Short, efficient syntheses of pyrrole α-amides

We report an inexpensive method for producing a diverse array of pyrrole amides on a large scale and in good yield. The synthetic sequence allows for the preparation of a number of pyrrole amide derivatives in excellent to moderate yields from commercially available compounds. The diketene adduct, in the presence of an amine nucleophile, provides an excellent method for acetoacetylation. For diversity and versatility, a second method utilizing Meldrum's acid was successfully employed for the preparation of additional acetoacetamide derivatives. Using the Knorr pyrrole synthesis, pyrrole amides were readily prepared from the oxime of the acetoacetamides. Copyright Taylor & Francis Group, LLC.

VICINAL MULTIFUNCTIONAL COMPOUNDS. TAUTOMERISM IN COLOURLESS 2-HYDROXIMINO-3-IMINOBUTYRANILIDES AND COLOURED 2-NITROSO-3-AMINOCROTONANILIDES

Condensation products of a 2-hydroximinoacetoacetanilide, 1, and amines have been isolated as colourless (or coloured) tautomers.An X-ray analysis established that the coloured condensation product with methylamine is a 2-nitroso-3-aminocrotonanilide, 3a.

Syntheses of 2-Arylimidazole Derivatives through Annelations Employing Benzylamines

Annelations of benzylamines with hydroximino derivatives of pentane-2,4-dione or of alkyl acetoacetates, acetoacetamides, and acetoacetanilides, afford imidazole derivatives and provide easy incorporation of the benzylic carbon and nitrogen in the heterocycle.The limits of the reaction have been explored.