42248-27-1Relevant articles and documents
Short, efficient syntheses of pyrrole α-amides
Huggins, Michael T.,Barber, Patrick S.,Florian, David,Howton, William
experimental part, p. 4226 - 4239 (2009/04/11)
We report an inexpensive method for producing a diverse array of pyrrole amides on a large scale and in good yield. The synthetic sequence allows for the preparation of a number of pyrrole amide derivatives in excellent to moderate yields from commercially available compounds. The diketene adduct, in the presence of an amine nucleophile, provides an excellent method for acetoacetylation. For diversity and versatility, a second method utilizing Meldrum's acid was successfully employed for the preparation of additional acetoacetamide derivatives. Using the Knorr pyrrole synthesis, pyrrole amides were readily prepared from the oxime of the acetoacetamides. Copyright Taylor & Francis Group, LLC.
Syntheses of 2-Arylimidazole Derivatives through Annelations Employing Benzylamines
Veronese, A.C.,Cavicchioni, G.,Servadio, G.,Vecchiati, G.
, p. 1723 - 1725 (2007/10/02)
Annelations of benzylamines with hydroximino derivatives of pentane-2,4-dione or of alkyl acetoacetates, acetoacetamides, and acetoacetanilides, afford imidazole derivatives and provide easy incorporation of the benzylic carbon and nitrogen in the heterocycle.The limits of the reaction have been explored.
