422508-26-7

Basic information

• Product Name: 2-fluoro-8-(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine
• Synonyms: 2-fluoro-8-(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine
• CAS NO: 422508-26-7
• Molecular Weight: 333.322
• Mol File: 422508-26-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-fluoro-8-(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-8-(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine(422508-26-7)
• EPA Substance Registry System: 2-fluoro-8-(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine(422508-26-7)

Safety Data

• Hazardous Substances Data: 422508-26-7(Hazardous Substances Data)

Upstream product

• 422508-25-6 8-(3,4,5-trimethoxy-benzyl)-9H-purine-2,6-diamine 
• 951-82-6 3,4,5-trimethoxyphenyl acetic acid 

Downstream Products

• 511253-46-6 PU₃F 

Relevant articles and documents

Development of a purine-scaffold novel class of hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

The first published synthesis and characterization of a purine-scaffold library of hsp90 inhibitors is presented. The purine-scaffold represents a platform for the creation of easily synthesizable and derivatizable soluble molecules that are amenable for oral administration. The most active compound of the series (71) exhibits binding to hsp90 comparable to the natural product derivative 17AAG that is now in Phase I clinical trial as a cancer therapeutic. 71 Induces the degradation of Her2 tyrosine kinase and arrests the MCF-7 breast cancer cell line at low micromolar concentrations (IC50=2 μM).