422552-13-4Relevant academic research and scientific papers
Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain
Cuzzucoli Crucitti, Giuliana,Métifiot, Mathieu,Pescatori, Luca,Messore, Antonella,Madia, Valentina Noemi,Pupo, Giovanni,Saccoliti, Francesco,Scipione, Luigi,Tortorella, Silvano,Esposito, Francesca,Corona, Angela,Cadeddu, Marta,Marchand, Christophe,Pommier, Yves,Tramontano, Enzo,Costi, Roberta,Di Santo, Roberto
, p. 1915 - 1928 (2015)
The development of HIV-1 dual inhibitors is a highly innovative approach aimed at reducing drug toxic side effects as well as therapeutic costs. HIV-1 integrase (IN) and reverse transcriptase-associated ribonuclease H (RNase H) are both selective targets
