4226-37-3

Basic information

• Product Name: 2-(2-Chloroethyl)pyridine hydrochloride
• Synonyms: 2-(2-Chloroethyl)pyridine hydrochloride;Pyridine, 2-(2-chloroethyl)-, hydrochloride;2-(2-Chloroethyl)Pyridine Hcl;2-(2-pyridinyl)ethyl chloride hydrochloride
• CAS NO: 4226-37-3
• Molecular Formula: C₇H₉ClN*Cl
• Molecular Weight: 178
• Mol File: 4226-37-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 209.4 °C at 760 mmHg
• Flash Point: 100 °C
• Appearance: /
• Vapor Pressure: 0.294mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(2-Chloroethyl)pyridine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Chloroethyl)pyridine hydrochloride(4226-37-3)
• EPA Substance Registry System: 2-(2-Chloroethyl)pyridine hydrochloride(4226-37-3)

Safety Data

• Hazardous Substances Data: 4226-37-3(Hazardous Substances Data)

Usage

General Description

2-(2-Chloroethyl)pyridine hydrochloride is a chemical compound that consists of a pyridine ring with a chloroethyl group attached to it. 2-(2-Chloroethyl)pyridine hydrochloride exists in the form of a hydrochloride salt, which means it is a positively charged ion combined with a negatively charged chloride ion. It is commonly used in organic synthesis and as a building block for the production of various pharmaceuticals, agrochemicals, and other specialty chemicals. The chloroethyl group makes this compound reactive, and it can be used in the synthesis of other compounds through various chemical reactions. However, it should be handled with caution as it is a potentially hazardous chemical and can cause irritation to the skin and respiratory system if not handled properly.

InChI:InChI=1/C7H8ClN.ClH/c8-5-4-7-3-1-2-6-9-7;/h1-3,6H,4-5H2;1H

Upstream product

• 103-74-2 2-(2-Hydroxyethyl)pyridine 

Downstream Products

• 102882-50-8 benzyl-(2-chloro-ethyl)-(2-[2]pyridyl-ethyl)-amine 

Relevant articles and documents

PIPERAZINONE-SUBSTITUTED TETRAHYDRO-CARBOLINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USES THEREOF

The present invention relates to piperazinone-substituted tetrahydro-carboline derivatives of formula (I): having the substituents as described herein which are melanin-concentrating hormone (MCH-1) receptor antagonists. The present invention also relates

New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics

A series of new 1-(heterocyclyalkyl)-4-(propionanilido)-4-piperidinyl methyl esters and methylene methyl ethers have been synthesized and pharmacologically evaluated. In the mouse hot-plate test, the majority of compounds exhibited an analgesia (ED50 1 mg/kg) superior to that of morphine. These studies revealed a pharmacological accommodation for many more structurally diverse and far bulkier aromatic ring systems than the corresponding components of the arylethyl groups of the prototypic methyl ester (carfentanil, 2) and methylene methyl ether (sufentanil, 3 and alfentanil, 4) 4-propionanilido analgesics. Compound 9A (methyl 1-[2-(1H-pyrazol-1-yl)-ethyl]-4-[(1-oxopropyl) phenylamino]-4-piperidinecarboxylate), which exhibited appreciable μ-opioid receptor affinity, was a more potent and short-acting analgesic, than alfentanil with less respiratory depression in the rat. On the other hand, the phthalimides 57A and 57B, which exhibited negligible affinity for opioid receptors associated with the mediation of nociceptive transmission (i.e., μ-, κ-, and δ-subtypes), displayed analgesic efficacy in all antinociception tests. In addition, while 57B, compared to clinical opioids, showed a superior recovery of motor coordination after regaining of righting reflex from full anesthetic doses in the rat rotorod test, 57A showed significantly less depression of cardiovascular function at supraanalgesic doses in the isoflurane-anesthetized rat.