42268-62-2

Basic information

• Product Name: 2-Propyn-1-amine, N-propyl-
• Synonyms: prop-2-ynyl-propyl-amine;N-propyl-N-prop-2-yn-1-amine;propyl(2-propynyl)amine;PROP-2-YN-1-YL(PROPYL)AMINE;N-propargylpropylamine;N-propylpropargylamine;propyl-prop-2-ynyl-amine
• CAS NO: 42268-62-2
• Molecular Formula: C6H11N
• Molecular Weight: 97.16
• Mol File: 42268-62-2.mol

Chemical Properties

• CAS DataBase Reference: 2-Propyn-1-amine, N-propyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propyn-1-amine, N-propyl-(42268-62-2)
• EPA Substance Registry System: 2-Propyn-1-amine, N-propyl-(42268-62-2)

Safety Data

• Hazardous Substances Data: 42268-62-2(Hazardous Substances Data)

Upstream product

• 107-10-8 propylamine 
• 624-65-7 2-propynyl chloride 
• 106-96-7 propargyl bromide 
• 16156-58-4 prop-2-yn-1-ol methanesulfonate 

Downstream Products

• 59300-32-2 prop-2-ynyl-propyl-thiocarbamic acid S-ethyl ester 

Relevant articles and documents

Efficient Conversion of Tertiary Propargylamides into Imidazoles via Hydroamination-Cyclization

A method to convert tertiary N -propargylamides into 1,2,4-trisubstituted imidazoles using ammonium chloride and zinc triflate as the catalyst is reported. The method is convenient, practical and employs conventional heating. It is also applicable to N -propargyl lactams and tends to populate the so-called 'lead-like' chemistry space.

Benzazepine Dicarboxamide Compounds

This invention relates to novel benzazepine dicarboxamide compounds of the formula wherein R1 to R4 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.

Ultrasound promoted the synthesis of N-propargylic β-enaminones

The synthesis of 14 novel N-propargylic β-enaminones from the reaction of β-alkoxy vinyltrihalomethyl[carboxyethyl] ketones [R 3C(O)CHC(R1)OMe, where R3 = CF3, CCl3, CO2Et and R1 = Me, Et, Pr, Bu, i-Pent, CH2CH2CO2Me] with propargyl amines [R 2NHCH2CCH, where R2 = Pr, PhCH2] is reported. Yields, solvents and reaction times needed for reaction completion, by microwave irradiation (MW), conventional thermal heating (TH) and under ultrasound irradiation (US) are compared. The best results were obtained under US irradiation in good to excellent yields (70-93%).

Organolanthanide-catalyzed intra- and intermolecular tandem C-N and C-C bond-forming processes of aminodialkenes, aminodialkynes, aminoalkeneynes, and aminoalkynes. New regiospecific approaches to pyrrolizidine, indolizidine, pyrrole, and pyrazine skeleto

This contribution describes catalytic tandem C-N and C-C bond-forming reactions involving the intramolecular hydroamination/bicyclization and intermolecular hydroamination/cyclization of olefins and alkynes using the organolanthanide complexes Cp'2/

Aliphatic propargylamines as cellular rescue agents

The present invention relates to the use of a group of propargylamines of the general formula (I) STR1 wherein R1 is hydrogen or CH3 and R2 is (CH2)n CH3 and n is an integer from 0 to 16, and salts thereof, as cellular rescue agents in the treatment and prevention of diseases in which cell death occurs by apoptosis. Some of the compounds of formula I are novel. The invention is also directed to the use of these compounds in the treatment of these diseases, as well as to processes for the preparation of the compounds.

Process for the preparation of 1,2,4-substituted imidazoles and related aminoalkylimidazole derivatives

The invention provides a new and efficient process for preparing 2,4(5)-substituted or 1,2,4-substituted imidazole derivatives. The invention also provides a process for preparing substituted aminoalkylimidazole derivatives, useful for the treatment of mammals having a variety of disease states, including stroke, epilepsy, hypertension, angina, migraine, arrhythmia, thrombosis, embolism, and the like. The invention also relates to novel aminoalkylimidazole compounds.

Preparations et heterocyclisations nucleophiles de thiols acetyleniques

Acetylenic thiols HCC(CH2)nSH 1a and HCCCH2Y(CH2)2SH 1b, isolated or prepared in situ from the corresponding thiouronium salts, have been treated with alkali to induce cyclization by intramolecular nucleophilic addition of the thiolate to the triple bond.Starting from the thiol 1a (n = 2) we only isolated thiacyclopent-2-ene 2a, which results from addition to the terminal carbon of the triple bond (yield 45 percent).Higher homologues 1a (n = 3,4), on the other hand, exclusively led to the heterocyclic products 3a resulting from addition to the non-terminal carbon of the triple bond.The best yield was obtained with 1a (n = 3), which led to 2-methylenethiacyclopentane 3a (n = 3) with a 59 percent yield.With the thiol 1a (n = 4), the yield was only 20 percent for 2-methylenethiacyclohexane 3a (n = 4), and with 1a (n = 5) only polymers were formed.When Y = S or N-n-Bu, the substrates 1b behaved like their carbon homologues 1a (n = 3) : yields were in the same range, and the seven-membered heterocycle 2b resulting from attack on the terminal carbon of the triple bond could not be detected.On the other hand, substance 1b (Y = O) mainly led to the seven-membered ring compound 2b.Furthermore, the presence of the heteroatom Y enhanced the possibility of prototropic rearrangement of the triple bond, leading to the new heterocycle 4b in appreciable amounts for Y = O,S.Generally speaking, acetylenic thiolates behave similarly to acetylenic alkoxides, and the same tentative interpretations can be put forward to account for the results obtained.