Welcome to LookChem.com Sign In|Join Free

CAS

  • or

42270-85-9

Post Buying Request

42270-85-9 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

42270-85-9 Usage

General Description

1,4-butanediyl bis(cyanoacetate) is a chemical compound also known as cyanoacetic acid 1,4-diester. It is a diester with two cyanoacetic acid groups attached to a butane-1,4-diol backbone. This chemical is used in the synthesis of pharmaceutical compounds and as a reagent in organic chemistry reactions. It is also used as a crosslinking agent in the production of polymers and as a building block for the creation of complex molecules. Additionally, 1,4-butanediyl bis(cyanoacetate) has potential applications in the fields of biochemistry and materials science due to its versatile properties and ability to form stable bonds with other molecules. However, it is important to handle this chemical with care, as it is toxic and should only be used by trained professionals in a controlled environment.

Check Digit Verification of cas no

The CAS Registry Mumber 42270-85-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,2,7 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 42270-85:
(7*4)+(6*2)+(5*2)+(4*7)+(3*0)+(2*8)+(1*5)=99
99 % 10 = 9
So 42270-85-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H12N2O4/c11-5-3-9(13)15-7-1-2-8-16-10(14)4-6-12/h1-4,7-8H2

42270-85-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(2-cyanoacetyl)oxybutyl 2-cyanoacetate

1.2 Other means of identification

Product number -
Other names 1,4-Butanediyl bis(cyanoacetate)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:42270-85-9 SDS

42270-85-9Downstream Products

42270-85-9Relevant articles and documents

Small molecule inhibitors of dynamin I GTPase activity: Development of dimeric tyrphostins

Hill, Timothy,Odell, Luke R.,Edwards, Jennifer K.,Graham, Mark E.,McGeachie, Andrew B.,Rusak, Jenny,Quan, Annie,Abagyan, Ruben,Scott, Janet L.,Robinson, Phillip J.,McCluskey, Adam

, p. 7781 - 7788 (2007/10/03)

Dynamin I is a GTPase enzyme required for endocytosis and is an excellent target for the design of potential endocytosis inhibitors. Screening of a library of tyrphostins, in our laboratory, against the GTPase activity of dynamin I gave rise to a ìèpotent lead, 2-cyano-3-(3,4- dihydroxyphenyl)thioacrylamide (1, IC50 70 μM). Our initial investigations suggested that only the dimeric form of 1 displayed dynamin I GTPase inhibitory activity. Subsequent synthetic iterations were based on dimeric analogues and afforded a number of small molecules, low μM potent, inhibitors of dynamin I GTPase, in particular, symmetrical analogues with a minimum of two free phenolic -OHs: catechol-acrylamide (9) (IC50 = 5.1 ± 0.6 μM), its 3,4,5-trihydroxy congener (10) (IC50 = 1.7 ± 0.2 μM), and the corresponding 3-methyl ether (11) (IC 50 = 9 ± 3 μM). Increasing the length of the central alkyl spacer from ethyl to propyl (22-24) afforded essentially identical activity with IC50's of 1.7 ± 0.2, 1.7 ± 0.2, and 5 ± 1 μM, respectively. No decrease in activity was noted until the introduction of a hexyl spacer. Our studies highlight the requirement for two free amido NHs with neither the mono-N-methyl (86) nor the bis-N-methyl (87) analogues inhibiting dynamin I GTPase. A similar effect was noted for the removal of the nitrile moieties. However, modest potency was observed with the corresponding ester analogues of 9-11: ethyl ester (90), propyl ester (91), and butyl ester (92), with IC50's of 42 ± 3, 38 ± 2, and 61 ± 2 μM, respectively. Our studies reveal the most potent and promising dynamin I GTPase inhibitor in this series as (22), which is also known as BisT.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 42270-85-9