42285-29-0Relevant academic research and scientific papers
PRMT5 INHIBITORS AND USES THEREOF
-
Paragraph 00775; 00776, (2016/04/20)
Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof:wherein Y1 is of formula (?) or formula (y):Ring Y is a 5- to 6-membered heteroaryl ring; and V4, V5, Rx, x, y, and n are as defined herein. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.
A versatile annulation route to primary-amino-substituted naphthyridine esters
Chen, Jinhua,Xu, Zijin,Wang, Tao,Lyssikatos, Joseph P.,Ndubaku, Chudi O.
, p. 89 - 92 (2014/01/06)
A straightforward four-step synthesis of primary-amino-substituted naphthyridine esters from commercially available cyano-pyridines was described. The route makes use of a condensation reaction between pyridinyl acetates with N,N-dimethylformamide dimethylacetal (DMF-DMA) to form ortho-cyano vinylogous carbamates. These intermediates can undergo facile cyclization with ammonium acetate in acetic acid to generate the corresponding naphthyridine esters in good synthetic yields. The synthesis of -primary-amino-substituted 7-azaquinoxaline was also described. Georg Thieme Verlag Stuttgart · New York.
AN EFFICIENT CHIRAL SYNTHESIS OF (+)-SESBANINE
Tomioka, Kiyoshi,Koga, Kenji
, p. 2321 - 2324 (2007/10/02)
(+)-Sesbanine was effectively synthesized from 4-methylnicotinonitrile and 1-malic acid.
