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Usage

Uses

Used in Pharmaceutical Industry:
2-(4-chlorophenyl)-2-methyl-propan-1-amine is used as a purinergic receptor P2X3 antagonist for the treatment of chronic pain. Its application is based on its ability to selectively block the P2X3 receptor, which is involved in the transmission of pain signals. By inhibiting this receptor, the compound can effectively alleviate chronic pain conditions, providing relief to patients suffering from various types of pain.

Upstream product

• 30568-32-2 2-(4-chlorophenyl)-2-methylpropanenitrile 

Relevant academic research and scientific papers

Synthesis of indolines by copper-mediated intramolecular aromatic C-H amination

A Cu(OAc)2-mediated intramolecular aromatic C-H amination proceeds with the aid of a picolinamide-type bidentate coordination group to deliver the corresponding indolines in good yields. The reaction occurs smoothly even under noble-metal-free conditions, and in some cases the use of an MnO2 terminal oxidant renders the process catalytic in Cu. The mild oxidation aptitude of Cu(OAc)2 and/or MnO2 accommodates the formation of electron-rich thiophene-and indole-fused indoline analogues. The Cu-based system can provide an effective approach to various indolines of potent interest in pharmaceutical and medicinal chemistry.

NEW COMPOUNDS I/418

There is provided compounds of formula I, wherein R1 to R7 have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

SULFONAMIDE COMPOUNDS

Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.